Evidence map›Paper›PMID 39758843›Full record

ReviewTurkish journal of biology = Turk biyoloji dergisi2024

Organ-on-a-chip platforms for drug development, cellular toxicity assessment, and disease modeling.

Muhammad Maaz Khurram, Göktürk Cinel, Özlem Yeşil Çeliktaş, Erdal Bedir

Abstract readReview
In one paragraph

Review in Turkish journal of biology = Turk biyoloji dergisi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muhammad Maaz KhurramDepartment of Bioengineering, İzmir Institute of Technology, İzmir, Turkiye.ORCID https://orcid.org/0009-0007-2117-9897
Göktürk CinelDepartment of Bioengineering, İzmir Institute of Technology, İzmir, Turkiye.ORCID https://orcid.org/0000-0001-5334-7815
Özlem Yeşil ÇeliktaşDepartment of Bioengineering, Faculty of Engineering, Ege University, İzmir, Turkiye.ORCID https://orcid.org/0000-0003-4509-2212
Erdal BedirDepartment of Bioengineering, İzmir Institute of Technology, İzmir, Turkiye.ORCID https://orcid.org/0000-0003-1262-063X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organs-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.

Indexed as

biomimeticsdisease modelingdrug efficacy screeningdrug toxicity screeningmicrofluidicsOrgan-on-a-chip

Identifiers

PMID39758843
PMCPMC11698198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.