Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue.

Camilo Cano, Amir Gholampour, Marc van Sambeek, Richard Lopata, Min Wu

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Article in Photoacoustics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Camilo CanoDepartment of Biomedical Engineering, Eindhoven University of Technology, De Rondom 70, Eindhoven, The Netherlands.

Amir GholampourDepartment of Biomedical Engineering, Eindhoven University of Technology, De Rondom 70, Eindhoven, The Netherlands.

Marc van SambeekDepartment of Vascular Surgery, Catharina Ziekenhuis Eindhoven, Michelangelolaan 2, The Netherlands.

Richard LopataDepartment of Biomedical Engineering, Eindhoven University of Technology, De Rondom 70, Eindhoven, The Netherlands.

Min WuDepartment of Biomedical Engineering, Eindhoven University of Technology, De Rondom 70, Eindhoven, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoacoustic imaging (PAI) is a developing image modality that benefits from light-matter interaction and low acoustic attenuation to provide functional information on tissue composition at relatively large depths. Several studies have reported the potential of dichroism-sensitive photoacoustic (DS-PA) imaging to expand PAI capabilities by obtaining morphological information of tissue regarding anisotropy and predominant orientation. However, most of these studies have limited their analysis to superficial scanning of samples, where fluence effects are negligible. Herein, we present a mathematical model for the in-depth analysis of the DS-PA signal of biological samples, focusing on estimating tissue orientation. Our model is validated with a B-scan setup for DS-PA imaging in ex-vivo porcine tendon samples, for which collagen displays optical anisotropy. Results show that for in-depth DS-PA imaging, the accumulative fluence modulation due to dichroism overcomes the effect of absorption dichroism affecting the measured signals; however, this effect can be corrected based on the presented model for determining fiber orientation.

Indexed as

Anisotropic tissueDichroism imagingOptic axis estimationPhotoacoustic imaging

Identifiers

PMID39758832

DOI10.1016/j.pacs.2024.100676

PMCPMC11697244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.