Evidence map›Paper›PMID 39758784›Full record

ArticleFrontiers in neurology2024

Association between GRIN2B polymorphism and Parkinson's disease risk, age at onset, and progression in Southern China.

Can Cui, Hongxia Li, Yiwen Bao, Yingying Han, Hongxiang Yu, Huan Song, Bei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Can Cui *Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Hongxia Li *Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yiwen Bao *Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yingying HanDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Hongxiang YuDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Huan SongDepartment of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Bei ZhangDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: The role of N-methyl-D-aspartate receptor 2B (GRIN2B) single nucleotide polymorphisms (SNPs) in influencing the risk and progression of Parkinson's disease (PD) is still unclear. This study aimed to assess the impact of GRIN2B genotype status on PD susceptibility and symptom progression. Methods: We enrolled 165 individuals with sporadic PD and 154 healthy controls, all of whom had comprehensive clinical data available at the start and during follow-up. We used chi-squared (χ Results: The prevalence of the GG + GT genotype and G allele was higher in patients compared to controls ( Conclusion: The GRIN2B rs219882 G allele is associated with increased PD susceptibility, particularly in LOPD. The carriers of the GG + GT genotype exhibited more rapid motor symptom progression, with a pronounced impact on rigidity and axial impairment.

Indexed as

axial impairmentGRIN2BLOPDmotor progressionParkinson’s diseaserigidity

Identifiers

PMID39758784
PMCPMC11697588

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.