ArticleACS omega2024
A Nanotheranostic Agent for Synergistic Antitumor Chemo/Phototherapy Prepared by Paclitaxel-Induced Self-Assembly of PEGylated Human Serum Albumin with Prolonged Circulation.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Albumin-based nanocarriers: Singularities, synthesis methods, clinical relevance and targeting strategies in cancer.Acta pharmaceutica Sinica. B · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of different therapies to enhance the efficacy and minimize adverse reactions has become popular recently. This approach leverages the complementary mechanisms of action of different treatments, which can lead to better therapeutic outcomes and reduced side effects. Human serum albumin (HSA) exhibits excellent drug loading ability and is often used for biomimetic tumor delivery in multidrug nanocarriers. However, albumin nanocarriers are often unstable with a short plasma half-life. Therefore, a nanotheranostic agent for synergistic antitumor chemo/phototherapy was designed to improve HSA's pharmacokinetic properties, including prolonged circulation. Cys34-specifically PEGylated HSA (PEG-cys34HSA) was used as the nanocarrier, hydrophobic paclitaxel (PTX) served as the chemotherapeutic drug and self-assembly inducer of nanoparticles (NPs), and near-infrared dye indocyanine green (ICG) was utilized for phototherapy and fluorescence imaging. PEGylation with 20 kDa polyethylene glycol (PEG
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Registered trials
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