ArticleACS omega2024
Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
This study presents the development and characterization of high yttrium-content phosphate-based glass-ceramic microspheres for potential applications in bone cancer radiotherapy treatment. The microspheres produced via flame spheroidization, followed by sieving, revealed a lack of aggregation and a narrow size distribution (45-125 μm) achieved across different yttrium oxide to glass ratio samples. Energy dispersive X-ray (EDX) analysis showed a significant increase in yttrium content within the microspheres with increasing yttrium oxide to glass ratio samples, ranging from approximately 1-39 mol % for 10Y-50Y microspheres, respectively. Concurrently, a proportional decrease in the phosphate, calcium, and magnesium content was observed. Further EDX mapping showed a homogeneous distribution of all elements throughout the microspheres, indicating uniform composition. X-ray diffraction profiles confirmed the amorphous nature of the starting P40 glass microspheres, while yttrium-containing microspheres exhibited crystalline peaks corresponding to cubic and hexagonal Y
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