Evidence map›Paper›PMID 39758619›Full record

ArticleACS omega2024

A Combined Approach for Rapid Dereplication of Herb-Drug Interaction Causative Agents in Botanical Extracts-A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe.

Suresh Chandra V A R Annam, William M Neal, Pankaj Pandey, Bharathi Avula, Kumar Katragunta, Islam Husain, Shabana I Khan, Igor Koturbash, Bill J Gurley, Ikhlas A Khan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Suresh Chandra V A R AnnamNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.
William M NealNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.
Pankaj PandeyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.ORCID https://orcid.org/0000-0001-9128-8254
Bharathi AvulaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.
Kumar KatraguntaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.ORCID https://orcid.org/0000-0002-8787-4602
Islam HusainNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.
Shabana I KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.ORCID https://orcid.org/0000-0001-6429-7219
Igor KoturbashDepartment of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States.
Bill J GurleyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.
Ikhlas A KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.
Amar G ChittiboyinaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, United States.ORCID https://orcid.org/0000-0002-7047-5373

Funding

In vitro screening of a unique botanical extract collection for herb-drug interaction (HDI) potentialR21AT011107 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI GURLEY, BILL · 2020 to 2021
$402k
FDA HHS U01 FD004246NCCIH NIH HHS R21 AT011107
6 · The paper itself

Abstract

Despite promising preliminary biology, natural products isolation efforts may be confounded when the active compound is not isolated during bioassay-guided purification or classical pharmacognostic research investigations. A more rational isolation procedure connecting the polypharmacology of an herb to its individual constituents must be applied to better detect bioactive molecules before tedious analytical steps are considered. While

Identifiers

PMID39758619
PMCPMC11696432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.