Evidence map›Paper›PMID 39758614›Full record

ArticleACS omega2024

Chitosan Nanoparticles, a Novel Drug Delivery System to Transfer Squalene for Hepatocyte Stress Protection.

Seyed Hesamoddin Bidooki, Lea Spitzer, Arnaud Petitpas, Javier Sánchez-Marco, Roberto Martínez-Beamonte, Roberto Lasheras, Virginie Pellerin, María J Rodríguez-Yoldi, María Angeles Navarro, Jesús Osada and 1 more

Abstract read
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In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Seyed Hesamoddin BidookiDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, C/Miguel Servet, 177, E-50013 Zaragoza, Spain.ORCID https://orcid.org/0000-0002-5612-5000
Lea SpitzerInstitute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM), E2S UPPA, CNRS, Université de Pau et des Pays de l'Adour, University Avenue, 64 012 Pau, France.
Arnaud PetitpasInstitute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM), E2S UPPA, CNRS, Université de Pau et des Pays de l'Adour, University Avenue, 64 012 Pau, France.
Javier Sánchez-MarcoDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, C/Miguel Servet, 177, E-50013 Zaragoza, Spain.
Roberto Martínez-BeamonteDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, C/Miguel Servet, 177, E-50013 Zaragoza, Spain.
Roberto LasherasLaboratorio Agroambiental, Servicio de Seguridad Agroalimentaria de la Dirección General de Alimentación y Fomento Agroalimentario, Gobierno de Aragón, Av. de Montañana, 1070B, E-50192 Zaragoza, Spain.
Virginie PellerinInstitute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM), E2S UPPA, CNRS, Université de Pau et des Pays de l'Adour, University Avenue, 64 012 Pau, France.
María J Rodríguez-YoldiInstituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, C/Miguel Servet, 177, E-50013 Zaragoza, Spain.
María Angeles NavarroDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, C/Miguel Servet, 177, E-50013 Zaragoza, Spain.
Jesús OsadaDepartamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, C/Miguel Servet, 177, E-50013 Zaragoza, Spain.
Susana C M FernandesInstitute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM), E2S UPPA, CNRS, Université de Pau et des Pays de l'Adour, University Avenue, 64 012 Pau, France.ORCID https://orcid.org/0000-0002-1295-5010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mediterranean diet is a well-known dietary pattern that has gained considerable popularity worldwide for its ability to prevent the progression of nonalcoholic fatty liver disease. This is largely attributed to the use of virgin olive oil as the primary source of fat, which contains a substantial amount of squalene, a natural antioxidant. In order to enhance the delivery of squalene and amplify its effects due to its highly hydrophobic nature, herein, squalene has been incorporated into chitosan nanoparticles. The characterization of the resulting nanoparticles was conducted via scanning electron microscopy, dynamic light scattering, ζ potential, Fourier transform infrared spectroscopy, and gas chromatography-mass spectrometry. Reactive oxygen species (ROS) generation and cell viability assays were conducted in oxidative and endoplasmic reticulum (ER) stress in AML12 and a TXNDC5-deficient AML12 cell line, which was generated by CRISPR/Cas9 technology. The results demonstrated that squalene was successfully encapsulated in chitosan nanoparticles and exhibited rapid and efficient cellular uptake at a 150 μM squalene concentration within 48 h. In conclusion, the encapsulation of squalene in chitosan nanoparticles, compared to the poly(d,l-lactide-

Identifiers

PMID39758614
PMCPMC11696419

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.