ArticleCurrent developments in nutrition2024
Impact of Small-Quantity Lipid-Based Nutrient Supplements on Pubertal Status of 9-13-Year Olds: A Follow-Up Study of the iLiNS-DYAD-Ghana Trial.
Article in Current developments in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00970866 (Efficacy of Lipid-based Nutrient Supplements), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants
Who cites it
2 citing papers in PubMed.
- Effect of Small-Quantity Lipid-Based Nutrient Supplementation on Children's Cortisol Concentration.Maternal & child nutrition · 2026Trial
- Randomized prenatal and postnatal nutrient supplementation shows no long-term impact on cortical gray matter in Ghanaian children.Frontiers in human neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Background: Early and delayed puberty are both associated with adverse health and psychosocial outcomes. Objectives: We assessed the impact of provision of small-quantity lipid-based nutrient supplement (SQ-LNS) to mothers during pregnancy and 6 mo postpartum and to their children aged 6-18 mo, on pubertal status. Methods: This study was a follow-up to a partially double-blind randomized controlled trial. At ≤20 wk, 1320 females were randomly assigned to receive daily: iron and folic acid during pregnancy and placebo 0-6 mo postpartum; or multiple micronutrients during pregnancy and 0-6 mo postpartum; or SQ-LNS during pregnancy and 0-6 mo postpartum and to their children from 6 to 18 mo. We re-enrolled 966 and 919 children at 9-11 y and 11-13 y, respectively. We calculated a total pubertal status score based on the Petersen Pubertal Development Scale (PDS) to assess growth spurt, skin changes, body hair, facial hair, voice break, breast development, and menstruation. Pubertal status was regressed on child's age to generate age-adjusted PDS z-scores (aPDSZ); we performed interaction and mediation analyses. Results: Mean ± standard deviation aPDSZ did not differ between the SQ-LNS and non-LNS groups at 9-11 y (0.01 ± 0.95 compared with -0.01 ± 0.98; Conclusion: Provision of SQ-LNS during the first 1000 d of life advanced pubertal status among females. Trial registration number: This trial was registered at clinicaltrials.gov as NCT00970866 (https://clinicaltrials.gov/ct2/show/record/NCT00970866).
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