ArticleHeliyon2025
Investigating the effect of femtosecond laser pulses on noscapine and curcumin cellular uptake and improving drug delivery in gastric cancer cells.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Curcumin therapeutic potential in gastric cancer prevention, treatment and metastasis suppression.Discover oncology · 2026Review
- Recent advances in infections as risk factors for lymphoma: a review of the effects of viral, bacterial, and fungal infections in lymphoma.Archives of microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MKN45 cell line, a type of gastric cancer cell, exhibits resistance to chemotherapy agents through various mechanisms. Curcumin and noscapine, two plant-derived anticancer compounds, exhibit selective cytotoxicity towards cancer cells. However, their bioavailability is poor both in vitro and in vivo. In this study, we used femtosecond laser pulses in the near-infrared region (central wavelength of 1040 nm) with a pulse duration of 200 fs, a beam diameter of 4 mm, and different pulse energies and average powers to perforate the plasma membrane. We standardized the necessary conditions while minimizing cellular necrosis. MKN45 cells were treated with 25-200 μM curcumin and noscapine for 24 h after irradiation with an optimized femtosecond laser exposure (40 mW, 40sec) or without irradiation. The MTT cell viability assay revealed that pre-treatment with femtosecond (fs) laser pulses significantly increased cellular sensitivity to the treatment. Overall, the findings suggest that fs laser pulses irradiation enhance the bioavailability of both curcumin and noscapine. The combined treatment of femtosecond laser pulses and drugs can improve the drug's efficacy and the overall treatment outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.