ArticleHeliyon2025
Amikacin-loaded selenium nanoparticles improved antibacterial and antibiofilm activity of amikacin against bovine mastitis-causing
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Selenium Nanoparticles as Versatile Delivery Tools.Pharmaceutics · 2025Review
- Recent Trends in Bioinspired Metal Nanoparticles for Targeting Drug-Resistant Biofilms.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Colistin-Conjugated Selenium Nanoparticles: A Dual-Action Strategy Against Drug-Resistant Infections and Cancer.Pharmaceutics · 2025Article
- Research on the prediction model of mastitis in dairy cows based on time series characteristics.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antibiotic resistance in various microorganisms has become one of the most serious health problems worldwide. The use of nanoparticles in combination with conventional antibiotics is one of the recent efforts to overcome these challenges. This study aims to synthesize and evaluate the possibility of using amikacin-loaded selenium nanoparticles as antibacterial agent against multidrug-resistant Methods: Selenium nanoparticles (SeNPs) were synthesized through chemical reduction of sodium selenite using L-cysteine. Loading of amikacin on selenium nanoparticles was done by mixing both in solution and confirmed by UV-Vis spectroscopy, XRD, SEM, and DLS. Antibacterial properties of obtained nanoparticles against Results: Synthetized SeNPs and amikacin-loaded selenium nanoparticles (SeNPs@AMK) exhibited spherical appearances and 80.4 % of Se° had a diameter of 120 nm. SeNPs and SeNPs@AMK exhibited antibacterial effects against Conclusions: The results of this study suggest the antimicrobial properties of SeNPs and the reduction in the effective concentration of nanoparticle-loaded amikacin. Therefore, loading of antibiotics on the surface of nanoparticles may be used as a strategy to deal with the growing problem of drug resistance.
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Registered trials
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