Evidence map›Paper›PMID 39757975›Full record

ArticleHuman brain mapping2025

Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water.

Amanda L Rodrigue, Emma E M Knowles, Josephine Mollon, Samuel R Mathias, Juan Manuel Peralta, Ana C Leandro, Peter T Fox, Peter Kochunov, Rene L Olvera, Laura Almasy and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda L RodrigueDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-3403-6349
Emma E M KnowlesDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Josephine MollonDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Samuel R MathiasDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Juan Manuel PeraltaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
Ana C LeandroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
Peter T FoxResearch Imaging Institute, University of Texas Health San Antonio, San Antonio, Texas, USA.
Peter KochunovDepartment of Psychiatry, University of Texas Health San Antonio, San Antonio, Texas, USA.
Rene L OlveraDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
Laura AlmasyDepartment of Genetics, Perelman School of Medicine, and the Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, Texas, USA.
David C GlahnDepartment of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Workforce Development CoreU54HG013247 · NHGRI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SARAH A. WILLIAMS-BLANGERO · 2023 to 2026
$10.5M
Quantitative Trait Locus Mapping in Human PedigreesR37MH059490 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2001 to 2010
$6.8M
Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for ProgressP30AG059305 · NIA · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Gladys E. Maestre · 2018 to 2026
$5.8M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Genetics of Brain Structure and FunctionR01MH078111 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2006 to 2014
$4.5M
Amish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3M
Genetics of Brain Structure and FunctionR01MH078143 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2006 to 2014
$4.3M
Imaging Genomics of the Aging BrainR01AG058464 · NIA · YALE UNIVERSITY · PI BLANGERO, JOHN, GLAHN, DAVID C · 2018 to 2022
$3.9M
Towards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7M
Genetics of Brain Structure and Function: Genome-Wide AssociationR01MH083824 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2008 to 2013
$3.3M
Lifespan Vascular Biology on White MatterRF1NS114628 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2020 to 2020
$3.1M
NHGRI NIH HHS U54 HG013247NIA NIH HHS P30 AG059305NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG058464NIBIB NIH HHS R01 EB015611NIH HHS S10 OD023696NIMH NIH HHS MH059490NIMH NIH HHS MH078111NIMH NIH HHS MH078143NIMH NIH HHS MH083824NIMH NIH HHS R01 MH059490NIMH NIH HHS R01 MH078111NIMH NIH HHS R01 MH078143NIMH NIH HHS R01 MH083824NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH133812NIMH NIH HHS R37 MH059490NIMH NIH HHS RF1 MH123163NIMH NIH HHS U01 MH108148NINDS NIH HHS R01 NS114628NINDS NIH HHS RF1 NS114628
6 · The paper itself

Abstract

Phenotypic and genetic relationships between white matter microstructure (i.e., fractional anisotropy [FA]) and peripheral inflammatory responses (i.e., circulating cytokines) have important implications for health and disease. However, it is unclear whether previously discovered genetic correlations between the two traits are due to tissue-specific white matter architecture or increased free water in the extracellular space. We applied a two-compartment model to diffusion tensor imaging (DTI) data and estimated tissue-specific white matter microstructure (FA

Indexed as

Diffusion Tensor ImagingInflammationWhite MatterAdultBrainFemaleHumansInterleukin-8MaleMiddle AgedTumor Necrosis Factor-alphaWaterYoung AdultCXCL8 protein, humanInterleukin-8TNF protein, humanTumor Necrosis Factor-alphaWaterdiffusion tensor imagingfree water volumegenetic correlationsperipheral proinflammatory cytokines

Identifiers

PMID39757975
PMCPMC11702472

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.