Evidence map›Paper›PMID 39757951›Full record

ReviewJournal of cellular physiology2025

Physiological Insights Into the Role of Pericytes in Spinal Cord Injury.

Haiming Jin, Jessica Rawlins, Yiqi Chen, Xiaohang Zheng, Oscar Charlesworth, Junchun Chen, Gang Wang, Huoling Luo, Wenxiang Cheng, Zhong Alan Li and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Modulation of the Receptor Tyrosine Kinase TIE2/International journal of molecular sciences · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haiming JinDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jessica RawlinsSchool of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Yiqi ChenDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiaohang ZhengDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0002-5734-2138
Oscar CharlesworthSchool of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Junchun ChenShenzhen Institute of Advanced Sciences, Chinese Academy of Sciences, Shenzhen, China.
Gang WangShenzhen Institute of Advanced Sciences, Chinese Academy of Sciences, Shenzhen, China.
Huoling LuoShenzhen Institute of Advanced Sciences, Chinese Academy of Sciences, Shenzhen, China.
Wenxiang ChengShenzhen Institute of Advanced Sciences, Chinese Academy of Sciences, Shenzhen, China.
Zhong Alan LiDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P. R. China.
Sipin ZhuDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0002-0213-2635
Jiake XuDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0003-2021-8309

Funding

This study was partly funded by grants from the National Natural Science Funding of China (82172424, 82372396, 82350710800, 82374470, 82202757), Shenzhen Medical Research Fund B2302005), Outstanding Youth Fund of Zhejiang Province (LR22H060002), Zhejiang Medical and Health Science and Technology Plan Project (2022RC210, 2021KY212), and Wenzhou Major Science and Technology Innovation Project Approval Project (ZY2022007).
6 · The paper itself

Abstract

Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined with vessel-specific endothelial cells and actively contribute to maintaining the spinal cord's vascular network. Within the neurovascular unit (NVU), subtypes of pericytes characterized by various markers such as PDGFR-β, Desmin, CD146, and NG-2 are involved in vascular regeneration in SCI repair. Various pericyte signaling, pericyte-derived exosomes, and endothelial-pericyte interplay were revealed to participate in SCI repair or fibrotic scars. Through further understanding pericyte biology, it is aimed to accurately generate subtypes of pericytes and develop their therapeutic potential. This review focuses on recent advanced research and development of pericytes as a potential treatment for SCI.

Indexed as

PericytesSpinal Cord InjuriesAnimalsEndothelial CellsExosomesHumansNeovascularization, PhysiologicSignal TransductionSpinal Cordpericytephysiologyspinal cord injury

Identifiers

PMID39757951
PMCPMC11701711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.