Evidence map›Paper›PMID 39757911›Full record

ArticleACS synthetic biology2025

Enhancing Chitin Production as a Fermentation Byproduct through a Genetic Toolbox That Activates the Cell Wall Integrity Response.

An Nguyen, Isabell Tunn, Merja Penttilä, Alexander D Frey

Abstract read
In one paragraph

Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

An NguyenDepartment of Bioproducts and Biosystems, Aalto University, Espoo 02150, Finland.ORCID 0000-0001-8919-5534
Isabell TunnDepartment of Bioproducts and Biosystems, Aalto University, Espoo 02150, Finland.ORCID 0000-0003-0853-8908
Merja PenttiläDepartment of Bioproducts and Biosystems, Aalto University, Espoo 02150, Finland.
Alexander D FreyDepartment of Bioproducts and Biosystems, Aalto University, Espoo 02150, Finland.ORCID 0000-0002-4371-0227

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Often, the value of the whole biomass from fermentation processes is not exploited, as commercial interests are focused on the main product that is typically either accumulated within cells or secreted into the medium. One underutilized fraction of yeast cells is the cell wall that contains valuable polysaccharides, such as chitin, known for its biocompatibility and biodegradability, which are thought of as valuable properties in diverse industries. Therefore, the valorization of waste biomass from fermentation to coproduce chitin could significantly improve the overall profitability and sustainability of biomanufacturing processes. Previous studies revealed that environmental stresses trigger the cell wall integrity (CWI) response, leading to an increased level of chitin synthesis as a protective measure. In this study, we evaluated the use of the key regulatory genes of the CWI response,

Indexed as

Cell WallChitinSaccharomyces cerevisiaeBiomassFermentationrho GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsChitinrho GTP-Binding ProteinsSaccharomyces cerevisiae Proteinscell wall integrity pathwaychitincoproductionPKC1RHO1Saccharomyces cerevisiae

Identifiers

PMID39757911
PMCPMC11744920

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.