ArticleCancer medicine2025
The Impact of Chemotherapy and Body Mass Index on Cancer-Related Fatigue in Colon Cancer Patients: A PROFILES-Registry Study.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Fatigue 5 years after treatment for rectal cancer – results from the QoLiRECT studyActa oncologica (Stockholm, Sweden) · 2026Article
- Symptom clusters and sentinel symptoms in colorectal cancer patients during post-operative chemotherapy.Frontiers in oncology · 2026Article
- Construction of a predictive model for the risk of moderate-to-severe cancer-related fatigue in colorectal cancer chemotherapy patients: an interpretable machine learning approach.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
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7 authors.
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Abstract
backgroundInflammation has been reported to drive cancer-related fatigue (CRF). As both obesity and chemotherapy promote inflammatory responses, obese cancer patients may be at risk of more severe CRF, especially when receiving chemotherapy.
methodsWe analysed data of 333 colon cancer patients from four hospitals in the Netherlands (data derived from the PROCORE study). Fatigue was assessed with the general fatigue subscale of the Multidimensional Fatigue Inventory at four timepoints: at inclusion (T1), 4 weeks after surgery (T2), and 1 (T3) and 2 years (T4) after diagnosis. Linear mixed-effects models were applied to evaluate the interaction between chemotherapy and body mass index (BMI) on the trajectory of fatigue.
resultsThe two-way interactions between time and chemotherapy (p = 0.047) and between time and BMI on fatigue (p = 0.041) were significant. Patients scheduled for chemotherapy reported more fatigue during the treatment phase, while patients not treated with chemotherapy showed a stable trajectory. Obese patients reported more fatigue at follow-up compared to patients with a healthy BMI. The three-way interaction between time, chemotherapy and BMI was not significant (p = 0.39). However, obese chemotherapy-treated patients reported the highest fatigue 2 years after treatment (12.8, 95% CI: 10.6-14.9). Their mean fatigue score was higher compared to baseline (9.2, 95% CI: 7.3-11.0, p < 0.001) and obese patients not treated with chemotherapy (9.6, 95% CI: 7.0-12.2, p = 0.02). Moreover, this group reported more fatigue compared to healthy (8.1, 95% CI: 5.5-10.9, p < 0.001) and overweight (9.7, 95% CI: 7.2-12.3, p = 0.019) chemotherapy-treated patients.
conclusionThis study indicates that chemotherapy and BMI both influence long-term fatigue in colon cancer patients. Proactive monitoring for CRF and lifestyle interventions may be needed for chemotherapy-treated patients with a high BMI.
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