Evidence map›Paper›PMID 39757670›Full record

ArticleCurrent medical imaging2025

Magnetic Resonance Imaging Study on Older Patients with Cognitive Impairment and Depression.

Shuang Zhang, Yuping Qin, Meng Ding, Jining Yang, Tao Zhang

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Article in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shuang ZhangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Yuping QinSchool of Artificial Intelligence, Neijiang Normal University, Neijiang, Sichuan, P.R. China.
Meng DingSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Jining YangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Tao ZhangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnderstanding brain changes in older patients with depression and their relationship with cognitive abilities may aid in the diagnosis of depression in this population. This study aimed to explore the association between brain lesions and cognitive performance in older patients with depression.

methodsWe utilized magnetic resonance imaging data from a previous study, which included older adults with and without depression. Smoothed Regional Homogeneity (ReHo) and local brain Amplitude of Low-frequency Fluctuation (ALFF) values were assessed to examine brain activity.

resultsThe analysis revealed decreased ReHo in the left middle temporal gyrus, left middle frontal gyrus, and left precuneus, as well as increased local ALFF in the right middle occipital gyrus, left postcentral gyrus, and right precentral gyrus in older patients with depression. These alterations may contribute to behavioral and cognitive changes. However, no significant relationship was found between ReHo values and Montreal Cognitive Assessment (MoCA) scores. In contrast, increased local ALFF in the left postcentral gyrus and right precentral gyrus was negatively correlated with MoCA scores.

conclusionThis study demonstrated a significant association between regional brain alterations in patients with depression and cognitive behavior. Thus, this work identified functional brain regions and cognitive performance in older adults with depression, highlighting specific brain regions that play a crucial role in cognitive abilities in this population.

Indexed as

BrainCognitive DysfunctionDepressionMagnetic Resonance ImagingAgedFemaleHumansMaleMiddle AgedCorrelation analysis of cognitive abilityDepressionDifference analysisMagnetic resonance imaging (MRI)Montreal cognitive assessment (MoCA).Older patients

Identifiers

PMID39757670
PMCPMC12817175

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