Evidence map›Paper›PMID 39757636›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2025

Synthesis, Antimicrobial Activity, DFT, Molecular Docking, and Dynamic Simulations of Trityl Mannopyranoside Derivatives for Potential Antibacterial Agents.

Sabina Akter, Sarkar M A Kawsar, Gassoumi Bouzid, Mabrouk Horchani, Md Z H Bulbul, Houcine Ghalla, Hichem Ben Jannet, Supriyo Saha, Yuki Fujii, Kabir M Uddin and 3 more

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Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Sabina AkterLaboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.
Sarkar M A KawsarLaboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.ORCID 0000-0001-7964-9117
Gassoumi BouzidLaboratory of Advanced Materials and Interfaces (LIMA), Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5000, Monastir, Tunisia.
Mabrouk HorchaniQuantum and Statistical Physics Laboratory, Faculty of Science, University of Monastir, Monastir, 5079, Tunisia.
Md Z H BulbulLaboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.
Houcine GhallaLaboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11Es39), Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir, 5000, Tunisia.
Hichem Ben JannetLaboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11Es39), Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, Monastir, 5000, Tunisia.
Supriyo SahaDepartment of Pharmaceutical Chemistry, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun- 248007, Uttarakhand, India.
Yuki FujiiGraduate School of Pharmaceutical Sciences, Nagasaki International University, 2825-7, Huis Ten Bosch, Sasebo, 859-3298, Japan.
Kabir M UddinDepartment of Biochemistry and Microbiology, North South University, Bashundhara, Dhaka, 1217, Bangladesh.
Ajmal R BhatDepartment of Chemistry, RTM Nagpur University, Nagpur, 440033, India.
Sumeer AhmedPostgraduate and Research Department of Chemistry, The New College (Autonomous), University of Madras, Chennai, 600 014, India.
Yasuhiro OzekiGraduate School of NanoBio Sciences, Yokohama City University, 22-2, Seto, Kanazawa-Ku, Yokohama, 236-0027, Japan.

Funding

Ministry of Science and Technology (MoST), Bangladesh 39.00.0000.009.99.024.22-901/SRG-226640
6 · The paper itself

Abstract

aimThere is an urgent need for new antimicrobial compounds with alternative modes of action for the treatment of drug-resistant bacterial and fungal pathogens.

backgroundCarbohydrates and their derivatives are essential for biochemical and medicinal research because of their efficacy in the synthesis of biologically active drugs.

objectiveIn the present study, a series of methyl α-D-mannopyranoside (MMP) derivatives (2-6) were prepared via direct acylation, and their biological properties were characterized.

methodsThe structures of synthesized compounds were established by analyzing their physicochemical, elemental, and spectroscopic data and evaluating their in vitro antimicrobial activities through

resultsIn the antibacterial study, compound 3 was found to be mostly active toward most of the organisms, exhibiting maximum inhibition of

conclusionOur synthetic, antimicrobial, and in silico experiments revealed that MMP derivatives exhibit potential activity, providing a therapeutic target for bacteria and fungi.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsDensity Functional TheoryMannoseMolecular Docking SimulationBacillus subtilisMicrobial Sensitivity TestsMolecular Dynamics SimulationMolecular StructurePseudomonas aeruginosaStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsMannoseAntimicrobial activitiesBacillus subtilis (6CGQ)DFTmannopyranoside derivativesmolecular dockingmolecular dynamics.

Identifiers

PMID39757636

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