ArticlePharmaceutical nanotechnology2026
Development of Nanoemulsion-based Gel of Betulin for the Treatment of Psoriasis-Like Skin Inflammation in a Small Animal Model.
Article in Pharmaceutical nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction/ Background: This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment. MATERIALS AND
methodsThe prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%).
resultsThe gel demonstrated skin-compatible pH and good spreadability. The developed gel showed slower release compared to nanoemulsion. In vivo pharmacokinetics demonstrated elevated AUC (55835.1 μg/cm DISCUSSION: Provided with enhanced skin retention, improved hydration, and lipid content, along with significant therapeutic efficacy in psoriasis treatment, betulin-loaded nanoemulsion gel demonstrated prolonged drug release and notably reduced PASI scores and cytokine levels, highlighting its effectiveness against psoriasis.
conclusionThis highlights the promising potential of NEG for topical psoriasis management.
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