Evidence map›Paper›PMID 39757450›Full record

ArticleFEBS letters2025

The [2Fe-2S] cluster of mitochondrial outer membrane protein mitoNEET has an O

Thao Nghi Hoang, Meritxell Wu-Lu, Alberto Collauto, Peter-Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M Roessler, Kourosh H Ebrahimi

Abstract read
In one paragraph

Article in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Emerging role of mitoNEET as mitochondrial sensor of hypoxia.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thao Nghi HoangInstitute of Pharmaceutical Science, King's College London, UK.
Meritxell Wu-LuDepartment of Chemistry, Technical University of Berlin, Germany.
Alberto CollautoDepartment of Chemistry and Centre for Pulse EPR Spectroscopy (PEPR), Imperial College London, UK.
Peter-Leon HagedoornDepartment of Biotechnology, Delft University of Technology, TU Delft, The Netherlands.ORCID https://orcid.org/0000-0001-6342-2022
Madalina AlexandruInstitute of Pharmaceutical Science, King's College London, UK.
Maike HenschelInstitute of Pharmaceutical Science, King's College London, UK.
Shahram KordastiComprehensive Cancer Center, King's College London, UK.
Maria Andrea MroginskiDepartment of Chemistry, Technical University of Berlin, Germany.
Maxie M RoesslerDepartment of Chemistry and Centre for Pulse EPR Spectroscopy (PEPR), Imperial College London, UK.
Kourosh H EbrahimiInstitute of Pharmaceutical Science, King's College London, UK.ORCID https://orcid.org/0000-0001-6628-944X

Funding

ECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6M
Deutsche Forschungsgemeinschaft EXC 2008-390540038EPSRC EP/T031425/1EPSRC EP/W005794/1European Cooperation in Science and Technology CA21115NCI NIH HHS U10 CA021115Royal Society for an International Exchanges Grant IES\R1\221117Royal Society for an International Exchanges Grant RGS\R1\231135
6 · The paper itself

Abstract

The mitochondrial outer membrane iron-sulphur ([Fe-S]) protein mitoNEET has been extensively studied as a target of the anti-inflammatory and type-2 diabetes drug pioglitazone and as a protein affecting mitochondrial respiratory rate. Despite these extensive past studies, its molecular function has yet to be discovered. Here, we applied an interdisciplinary approach and discovered an explicit nitric oxide (NO) access site to the mitoNEET [2Fe-2S] cluster. We found that O

Indexed as

Iron-Sulfur ProteinsMitochondrial MembranesMitochondrial ProteinsNitric OxideOxygenHumansMitochondriaPioglitazoneSignal TransductionCISD1 protein, humanIron-Sulfur ProteinsMitochondrial ProteinsNitric OxideOxygenPioglitazonegasotransmitterH2Shypoxiairon–sulphur clustermitoNEETnitric oxide

Identifiers

PMID39757450
PMCPMC11995679

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.