Evidence map›Paper›PMID 39757433›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Quinizarin Gold(I) N-Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline-Resistant Leukaemia Cells: Synthesis and Biological Activity Studies.

Axel Steinbrueck, Matthew L Reback, Christoph Rumancev, Daniel Siegmund, Jan Garrevoet, Gerald Falkenberg, Axel Rosenhahn, Aram Prokop, Nils Metzler-Nolte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Axel SteinbrueckFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801, Bochum, Germany.ORCID https://orcid.org/0000-0001-6014-3204
Matthew L RebackFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801, Bochum, Germany.ORCID https://orcid.org/0009-0009-2740-3495
Christoph RumancevFaculty of Chemistry and Biochemistry, Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitaetsstrasse 150, 44801, Bochum, Germany.ORCID https://orcid.org/0000-0003-0286-506X
Daniel SiegmundFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801, Bochum, Germany.ORCID https://orcid.org/0000-0003-2476-8965
Jan GarrevoetDeutsches Elektronen-Synchrotron DESY, 22607, Hamburg, Germany.ORCID https://orcid.org/0000-0001-8696-0499
Gerald FalkenbergDeutsches Elektronen-Synchrotron DESY, 22607, Hamburg, Germany.ORCID https://orcid.org/0000-0002-2229-1027
Axel RosenhahnFaculty of Chemistry and Biochemistry, Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitaetsstrasse 150, 44801, Bochum, Germany.ORCID https://orcid.org/0000-0001-9393-7190
Aram ProkopDepartment of Pediatric Hematology/Oncology, Helios Clinics Schwerin, Wismarsche Straße 393-397, 19055, Schwerin, Germany.ORCID https://orcid.org/0000-0003-0866-0188
Nils Metzler-NolteFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801, Bochum, Germany.ORCID https://orcid.org/0000-0001-8111-9959

Funding

Blankenheimerdorf e.V.Bundesministerium für Bildung und Forschung 05K22PC1Deutsche Forschungsgemeinschaft STE 3245/1- 1Dr. Kleist FoundationKoch Foundation
6 · The paper itself

Abstract

New, asymmetric quinizarin-Au(I)-NHC complexes were designed, isolated, and fully characterised including by single crystal X-ray crystallography. Cytotoxicity studies showed effective growth inhibition in HeLa cervical cancer cells with IC

Indexed as

AnthracyclinesAnthraquinonesAntineoplastic AgentsCoordination ComplexesGoldHeterocyclic CompoundsLeukemiaMethaneCell Line, TumorCell ProliferationCrystallography, X-RayDoxorubicinDrug Resistance, NeoplasmDrug SynergismHeLa CellsHumansAnthracyclinesAnthraquinonesAntineoplastic AgentscarbeneCoordination ComplexesDoxorubicinGoldHeterocyclic CompoundsMethaneCancerDrug resistanceGoldMedicinal inorganic chemistryMetal-based drugsN-heterocyclic carbeneX-ray fluorescence

Identifiers

PMID39757433
PMCPMC11840658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.