Evidence map›Paper›PMID 39757280›Full record

ArticleScientific reports2025

Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway.

Liu Shengnan, Xi Jiayan, Sun Meng, Li Li, Cai Shengyun, Xu Mingjuan

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liu Shengnan *Department of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Xi Jiayan *Shanghai Pudong New Area Zhoupu Community Health Service Center, Shanghai, 201318, China.
Sun MengDepartment of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, 110004, China.
Li LiDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Cai ShengyunDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. caicai24@126.com.
Xu MingjuanDepartment of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. mingjuanxu@smmu.edu.cn.

Funding

"234" Discipline Climbing Program in Shanghai Changhai Hospital 2019YXK4Naval Medical University Youth Initiation Fund 2023QN062
6 · The paper itself

Abstract

Regulator of G protein signaling 1 (RGS1) is known to be highly expressed in various tumors, but its specific effects and regulatory mechanism in ovarian cancer (OC) progression are not well understood. To delve into the tumor biology, a predictive risk model for OC was developed, incorporating RGS1, PRKG2, CD24, and ABCB1, with RGS1 exhibiting the strongest correlation. The model's reliability and validity were confirmed through Kaplan-Meier analysis, receiver operating characteristic (ROC) curve, and principal component analysis (PCA). The risk score was validated as an independent indicator of overall survival, and a nomogram model was created to predict overall survival. Moreover, RGS1 expression was found to be up-regulated and associated with a poor prognosis in OC. Functional studies revealed that deleting RGS1 inhibited OC cell proliferation both in vitro and in vivo, while overexpression of RGS1 enhanced cell proliferation. Additionally, blocking the NF-kB pathway was shown to impede RGS1-induced proliferation, and overexpression of p65 partially reversed the effects of RGS1 deletion, promoting the tumorigenic properties of OC cells. These findings suggest that RGS1 could be a valuable biomarker for predicting prognosis and a potential novel therapeutic target for OC treatment.

Indexed as

NF-kappa BOvarian NeoplasmsRGS ProteinsSignal TransductionAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceMiddle AgedPrognosisNF-kappa BRGS1 protein, humanRGS ProteinsCell cycleNF-κB signalingOvarian cancerRGS1

Identifiers

PMID39757280
PMCPMC11701083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.