ArticlePsicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS2025
The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic.
Article in Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLimited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.
objectiveThis article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19.
methodsA total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated.
resultsSpearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (Spearman's rho = .230, p = .021), obsessive-compulsive symptoms (Spearman's rho = .201, p = .042). The levels of IL-8 were negatively associated with the anxiety score (Spearman's rho = -.223, p = .028), obsessive-compulsive symptoms (Spearman's rho = -.252, p = .012), hyperarousal (Spearman's rho = -.221, p = .028). The levels of TNF-α were positively associated with the anxiety score (Spearman's rho = .201, p = .045), obsessive-compulsive symptoms (Spearman's rho = .222, p = .035).
conclusionGenerally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff.
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