Evidence map›Paper›PMID 39757209›Full record

ArticleItalian journal of pediatrics2025

Nickel-induced labial angioedema in a pediatric patient with orthodontic braces: a case report.

Fabrizio Leone, Alessandra Gori, Bianca Laura Cinicola, Giorgio Colletti, Elia Pignataro, Martina Capponi, Giulia Brindisi, Caterina Anania, Anna Maria Zicari

Erratum issuedAbstract readCase Reports
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In one paragraph

Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Fabrizio LeoneDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy. fabrizioleone22@gmail.com.ORCID http://orcid.org/0000-0001-8290-9020
Alessandra GoriDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Bianca Laura CinicolaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Giorgio CollettiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Elia PignataroDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Martina CapponiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Giulia BrindisiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Caterina AnaniaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Anna Maria ZicariDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAngioedema is a condition marked by sudden, intense swelling of the subcutaneous and submucosal tissues, typically associated with hypersensitivity reactions, genetic mutations, or reactions to medications. It can also result from contact with allergens such as nickel, leading to dermatitis. CASE PRESENTATION: A 12-year-old girl presented at our Pediatric Immunology and Allergology service with recurrent labial angioedema for over a year, linked to the consumption of legumes and tomatoes, and following the use of a metal flute. Despite a nickel-positive patch test and subsequent avoidance of nickel, her symptoms persisted. Further investigations to rule out other causes of angioedema were unproductive. It was later discovered that she had been wearing a nickel-containing orthodontic device applied a year earlier. The removal of this orthodontic device led to a cessation of the angioedema episodes, highlighting nickel as the likely trigger.

conclusionsThis case underscores the importance of considering prolonged nickel exposure from dental devices as a potential cause of angioedema. For patients predisposed to nickel hypersensitivity, using nickel-free alternatives such as ceramic for orthodontic appliances is crucial. Additionally, comprehensive allergen screening, including latex testing, should be conducted before the placement of such devices to prevent similar adverse reactions.

Indexed as

AngioedemaNickelChildFemaleHumansOrthodontic AppliancesPatch TestsNickelAngioedemaCase reportContact urticariaDental bracesNickel Allergy

Identifiers

PMID39757209
PMCPMC11702119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.