Evidence map›Paper›PMID 39757182›Full record

ArticleItalian journal of pediatrics2025

Clinical predictors for surfactant retreatment in preterm infants with respiratory distress syndrome: the results of a pooled analysis.

Carlo Dani, Chiara Poggi, Massimo Agosti, Massimo Bellettato, Pasqua Betta, Paolo Biban, Luigi Corvaglia, Raffaele Falsaperla, Carlo Forcellini, Diego Gazzolo and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Carlo DaniDepartment of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. carlo.dani@unifi.it.ORCID http://orcid.org/0000-0002-1639-621X
Chiara PoggiDepartment of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Massimo AgostiMaternal and Child Health Department, Del Ponte Hospital, A.O. Di Circolo Fondazione Macchi, Varese, Italy.
Massimo BellettatoDivision of Neonatology, Ospedale San Bortolo, Vicenza, Italy.
Pasqua BettaNeonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele of Catania, Catania, Italy.
Paolo BibanDepartment of Pediatrics, Pediatric and Neonatal intensive Care Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Luigi CorvagliaNeonatal Intensive Care Unit, Department of Medical and Surgical Sciences, IRCCS AOUBO, University of Bologna, Bologna, Italy.
Raffaele FalsaperlaNeonatal Intensive Care Unit and Neonatal Accompaniment Unit, San Marco Hospital, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", University of Catania, Catania, Italy.
Carlo ForcelliniDepartment of Pediatrics, Pediatric and Neonatal intensive Care Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Diego GazzoloDepartment of Maternal Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Alessandria, Italy.
Eloisa GittoDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Neonatal and Paediatric Intensive Care Unit, University of Messina, Messina, Italy.
Camilla GizziDivision of Neonatology, S. Giovanni Calibita Hospital Fatebenefratelli, Isola Tiberina, Rome, Italy.
Paola LagoNeonatal Intensive Care Unit and High-Risk Follow up program, Cà Foncello Regional Hospital, Azienda ULSS 2 Marca Trevigiana of Treviso, Treviso, Italy.
Gianluca ListaDivision of Neonatology, "V. Buzzi" Children's Hospital - ASST-FBF-Sacco, Milan, Italy.
Gianfranco MaffeiDivision of Neonatology, Neonatal Intensive Care Unit, Azienda Ospedaliero-Universitaria, Foggia, Italy.
Fabio MoscaNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy.
Marcello NapolitanoDivision of Neonatology and Neonatal Intensive Care Unit, Ospedale Evangelico Betania of Naples, Naples, Italy.
Gianfranco ScarpelliDivision of Neonatology and Neonatal Intensive Care Unit, Azienda Ospedaliero Universitaria of Cosenza, Cosenza, Italy.
Fabrizio SandriMaternal and Pediatrics Department, Maggiore Hospital, Bologna, Italy.
Daniele TrevisanutoDepartment of Pediatrics, Padua, Italy.
Giovanni VentoDivision of Neonatology, Catholic University of Rome, Rome, Italy.
Iuri CorsiniDepartment of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Simone PratesiDepartment of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Luca BoniSC Epidemiologia Clinica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino of Genova, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe issue of retreatment with surfactant of infants with respiratory distress syndrome (RDS) has been poorly investigated. Our aim was to identify possible clinical predictors of the need for multiple doses of surfactant in a large cohort of very preterm infants.

methodsData were analyzed from three previous studies on infants born between 25

resultsWe studied 448 infants. Among them 306 (68%) were treated with a single dose of surfactant and 142 (32%) were treated with multiple doses. Multivariable mixed effects logistic regression analysis showed that the odd of requiring multiple doses of surfactant was significantly lower in patients with higher gestational age (27-28 vs. 25-26 wks: OR 0.46, 95% C.l. 0.26-0.79; ≥29 vs. 25-26 wks: OR 0.34, 95% C.l. 0.13-0.85; overall P = 0.013), while it increased in infants born to mothers with hypertensive disorders of pregnancy (OR 2.53, 95% C.l. 1.49-4.31; P < 0.001) and with hemodynamically significant PDA (OR 2.74, 95% C.l. 1.66-4.53, P < 0.001).

conclusionsGestational age, hypertension in pregnancy, and hemodynamically significant PDA can predict the need for multiple doses of surfactant. Further investigation is needed to evaluate if these sub-groups of preterm infants represent specific phenotypes of RDS who deserve a peculiar surfactant treatment.

Indexed as

Infant, PrematurePulmonary SurfactantsRespiratory Distress Syndrome, NewbornFemaleGestational AgeHumansInfant, NewbornMaleRetreatmentRetrospective StudiesPulmonary SurfactantsMultiple dosePreterm infantsRespiratory distress syndromeSurfactant

Identifiers

PMID39757182
PMCPMC11702167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.