Evidence map›Paper›PMID 39756794›Full record

ArticleOphthalmology. Glaucoma

Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma.

Judy Figueroa, Erica Su, Vahid Mohammadzadeh, Sajad Besharati, Massood Mohammadi, Maryam Ashrafkhorasani, Simon K Law, Anne L Coleman, Joseph Caprioli, Robert E Weiss and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Judy FigueroaGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Erica SuGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Vahid MohammadzadehGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Department of Ophthalmology, University of Louisville, Louisville, Kentucky.
Sajad BesharatiGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Massood MohammadiDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana.
Maryam AshrafkhorasaniGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Simon K LawGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Anne L ColemanGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.
Joseph CaprioliGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Robert E WeissDepartment of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.
Kouros Nouri-MahdaviGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: nouri-mahdavi@jsei.ucla.edu.

Funding

Detection of Disease Progression in Advanced GlaucomaR01EY029792 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NOURI-MAHDAVI, KOUROS · 2020 to 2024
$1.9M
NEI NIH HHS R01 EY029792
6 · The paper itself

Abstract

purposeTo investigate the influence of baseline blood pressure (BP) on retinal nerve fiber layer (RNFL) rates of change (RoCs) in glaucoma patients with central damage or moderate to severe disease.

designProspective cohort study.

participantsOne hundred ten eyes with ≥ 4 RNFL OCT scans and ≥ 2 years of follow-up.

methodsGlobal RNFL RoCs were modeled with a Bayesian hierarchical model with subject- and sector-level random effects. Influence of baseline systolic and diastolic BP measures and their interactions with intraocular pressure (IOP) on global RNFL RoCs was investigated in prognostic models adjusting for relevant baseline demographic and clinical measures.

main outcome measuresMagnitude and direction of coefficients for BP, IOP, and their interaction for prediction of global RNFL RoCs. One-sided Bayesian P values denote posterior probability that a regression coefficient is greater than or less than zero, with P < 0.025 or P > 0.975 defining significance.

resultsAverage (standard deviation) 24-2 visual field mean deviation (MD) at baseline, follow-up time, and number of OCT scans were -8.8 (6.0) dB, 4.3 (0.5) years, and 8.3 (1.4), respectively. In multivariable analyses, female sex, Hispanic ethnicity (vs. White ethnicity), better baseline 24-2 MD, higher contrast sensitivity at 12 cycles per degree, presence of diabetes, and thicker central cornea predicted faster RNFL thinning. Adjusted for covariates, lower diastolic BP combined with higher IOP predicted faster RNFL RoCs. Parallel multivariable models incorporating systolic BP showed similar effects. Among various BP/IOP combinations, eyes with IOP at the 90th percentile and diastolic (systolic) BP at 10th percentile demonstrated the fastest RNFL thinning rates (-0.554 and -0.539 μm/year).

conclusionsLow BP and higher IOP at baseline predicted faster (worse) RNFL RoCs in glaucoma patients with central damage or moderate to advanced disease. Although there may be potential benefits to BP management in glaucoma patients, the therapeutic value of BP manipulation in glaucoma patients is yet to be established given the proven benefits of tight BP control in reducing cardiovascular morbidity and mortality. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Blood PressureGlaucomaIntraocular PressureNerve FibersOptic DiskRetinal Ganglion CellsAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesTomography, Optical CoherenceVisual FieldsBlood pressureGlaucomaIntraocular pressurePrognostic modelRetinal nerve fiber layer

Identifiers

PMID39756794
PMCPMC13070006

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.