ArticleOphthalmology2025
High-Density Lipoproteins Associated with Age-Related Macular Degeneration in the All of Us Research Program.
Article in Ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- From Retina to Vasculature: Oxidative Stress as a Common Mechanistic Link Between Age-Related Macular Degeneration and Cardiovascular Disease.Antioxidants (Basel, Switzerland) · 2026Review
- Reticular pseudodrusen load is associated with an increased risk of stroke.BMJ open ophthalmology · 2026Article
- Elevated serum high-density lipoprotein is positively associated with incident glaucoma among middle-aged and older adults: a national cohort in China.BMC ophthalmology · 2026Article
- CETP Renaissance with Obicetrapib.Current atherosclerosis reports · 2026Review
- High-Density Lipoprotein Cholesterol Levels and Risk of Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2026Article
- Bruch's membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Advances in materials science for ocular diseases induced by cardiovascular risk factors.Frontiers in bioengineering and biotechnology · 2025Review
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and age-related macular degeneration: insights from two observational studies.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeExtracellular lipoprotein aggregation is a critical event in age-related macular degeneration (AMD) pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk for AMD in the All of Us research program.
designCross-sectional retrospective data analysis.
participantsA total of 5028 healthy participants and 2328 patients with AMD from All of Us.
methodsParticipants with and without AMD were age, race, and sex matched in a 1:2 ratio, respectively. Smoking status, history of hyperlipidemia, and statin use were extracted in a binary manner. Statin use was further subcategorized into hepatically versus nonhepatically metabolized statins. Laboratory values for low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TGs) were also extracted, and outliers were excluded from analysis. The PLINK toolkit was used to extract single nucleotide polymorphisms (SNPs) associated with LDL and HDL dysregulation, as published in prior work. Odds ratio curves were computed to assess the risk between LDL, TG, and HDL versus AMD. All clinical and genetic variables were input into a multivariable logistic regression model, and odds ratios and P values were generated.
main outcome measuresStatistical significance of risk factors for AMD, thresholded at P ≤ 0.05.
resultsOn multivariable regression analysis, statin use and low and high HDL were significantly associated with increased AMD risk (P < 0.001 for all variables). Additionally, the multivariable regression implicated HDL-associated SNP's increased risk for AMD. Last, LPA was identified (P = 0.007) as a novel SNP associated with increased AMD risk.
conclusionsThere exists a U-shaped relationship between HDL and AMD risk, such that high and low HDL are significantly associated with increased AMD risk. Additionally, SNPs associated with HDL metabolism are associated with AMD risk. This analysis further establishes the role of HDL in AMD pathogenesis. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
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