ArticleAmerican journal of ophthalmology2025
Microcystoid Macular Edema in Epiretinal Membrane: Not a Retrograde Maculopathy.
Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Retinal glial cell removing during internal limiting membrane peeling is associated with higher-stage idiopathic epiretinal membrane.Eye and vision (London, England) · 2026Article
- Postoperative demarcation lines in rhegmatogenous retinal detachment: what en-face imaging reveals about visual outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Distinct retinal remodeling and visual prognostic factors in advanced epiretinal membranes with and without associated retinal break.BMC ophthalmology · 2026Observational
- Correlation of retinal imaging with presence of inner limiting membrane pores in idiopathic epiretinal gliosis.International journal of retina and vitreous · 2026Article
- Post-vitrectomy Macular Edema: Shedding Light on Incidence and Risk Factors.Ophthalmology and therapy · 2026Review
- Microcystic macular edema in eyes with idiopathic epiretinal gliosis: A retrospective analysis before and after vitreomacular surgery : Short title: microcystic macular edema in idiopathic epiretinal gliosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Visual Acuity Correlations of Preoperative OCT Morphological Parameters After Phacovitrectomy for Epiretinal Membrane.Journal of ophthalmology · 2026Article
- Epiretinal membrane peeling in eyes with pseudophakia: prognostic and morphological factors of visual outcomes.BMC ophthalmology · 2025Article
- Current Topics in OCT Applications in Vitreoretinal Surgery.Bioengineering (Basel, Switzerland) · 2025Review
- Adaptive Optics and Multimodal Retinal Imaging for Postoperative Evaluation in Patients With Epiretinal Membrane.Investigative ophthalmology & visual science · 2025Article
- Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes.Investigative ophthalmology & visual science · 2025Article
- The impact of epiretinal membrane stage and postoperative treatment on visual and anatomical outcomes following vitrectomy in eyes with preexisting macular edema.International journal of retina and vitreous · 2025Article
- En-Face OCT and Microperimetric Analysis of Intraretinal Microcysts in Eyes After Pars Plana Vitrectomy for Epiretinal Membrane.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
purposeTo investigate the incidence, clinical spectrum, and pathophysiology of microcystoid macular edema (MME) in 2 cohorts of patients with epiretinal membrane (ERM) and idiopathic full-thickness macular hole (FTMH).
designSingle-center, retrospective, interventional, cohort study.
methodsReview of clinical charts, structural and en-face optical coherence tomography (OCT), and fluorescein angiography (FA) imaging of ERM and FTMH eyes that underwent surgery with pars plana vitrectomy and internal limiting membrane (ILM) peel, with a minimum follow-up of 6 months. Histopathology analysis of 3 specimens: 2 human retinas and 1 human ILM.
resultsOne hundred seventy-two patients with ERM (123) and FTMH (49) were included in the study and followed up a mean of 9.1 ± 4.7 and of 8.2 ± 3.6 months, respectively. Preoperatively, MME was present in 27 of 123 eyes with ERM (21.9%), and in none of 49 eyes with FTMH (P < .001). MME was significantly associated with advanced ERM stages (P < .001). MME was typically located below continuous ERM-ILM adherence areas. FA in 46 ERM eyes showed capillary leakage in 36.4% of eyes without MME or cystoid macular edema (CME), in 39% of eyes with MME, and increased hyperfluorescence in CME. Postoperatively, new-onset MME appeared in 13 of 84 ERM eyes (15.5%) and in 1 FTMH eye (2%, P = .014). MME resolved in 7 of 40 ERM eyes with either preoperative or postoperative MME (17.9%) by 2.8 ± 1.5 months postsurgery. MME showed variable evolution postoperatively. The association between MME and postoperative best corrected visual acuity was significant only in univariate analysis (P = .037). Histopathology analysis showed anatomical continuity between Müller cells and ERM, suggesting a higher risk of iatrogenic damage in ERM eyes during peeling maneuvers.
conclusionsPostoperative MME was a frequent finding in ERM and a rare occurrence in FTMH, suggesting that ILM peeling alone may not be sufficient to cause MME. The morphology and clinical characteristics of ERM-related MME are unlikely related to neurodegenerative processes and rather attributable to Müller cell disruption and iatrogenic damage. The characteristics of MME and CME may overlap, blurring the differences between the 2 entities.
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