Evidence map›Paper›PMID 39756271›Full record

ArticleBiomaterials2025

Hydrogel-integrated exosome mimetics derived from osteogenically induced mesenchymal stem cells in spheroid culture enhance bone regeneration.

Changlu Xu, Zhi Li, Minjee Kang, Yiqing Chen, Ruoyu Sheng, Tara Aghaloo, Min Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changlu XuDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Zhi LiDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Minjee KangDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.
Yiqing ChenDepartment of Bioengineering, University of California, Riverside, CA, 92521, USA.
Ruoyu ShengDepartment of Bioengineering, University of California, Riverside, CA, 92521, USA.
Tara AghalooDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA. Electronic address: taghaloo@dentistry.ucla.edu.
Min LeeDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA. Electronic address: leemin@ucla.edu.

Funding

Tribbles homolog 3 and BMP-2 induced bone formationR01DE027332 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tara L Aghaloo, Min Lee · 2018 to 2026
$2.7M
Hydrogel delivery of DBM and exosome mimetics for bone repairR01DE031711 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Min Lee · 2022 to 2026
$1.8M
NIDCR NIH HHS R01 DE027332NIDCR NIH HHS R01 DE031711
6 · The paper itself

Abstract

Exosomes derived from mesenchymal stem cells (MSCs) offer a promising alternative to traditional cell-based therapies for tissue repair by mitigating risks associated with the transplantation of living cells. However, insufficient osteogenic capacity of exosomes diminishes their potential in bone tissue regeneration. Here, we report novel osteogenically induced exosome mimetics (EMs) integrated into injectable hydrogel carriers for improved bone regeneration. EMs were produced by a serial extrusion of MSCs cultured as spheroids during osteogenic induction. The prepared EMs were chemically anchored on a self-healing hydrogel assembled by guanidinylated hyaluronic acid and silica-rich nanoclays for sustained release of EMs. The administration of hydrogel-integrated EMs into mouse calvarial defects resulted in robust bone tissue regeneration. miRNA sequencing revealed altered expression of specific miRNAs in the EMs related to Wnt/β-catenin and Notch signaling pathways. Our study provides new insights into the development of advanced exosome-based cell-free therapies for bone tissue engineering.

Indexed as

Biomimetic MaterialsBone RegenerationExosomesHydrogelsMesenchymal Stem CellsOsteogenesisSpheroids, CellularAnimalsCells, CulturedMiceMicroRNAsSkullTissue EngineeringHydrogelsMicroRNAsBone regenerationExosome mimeticsmiRNAsMSC spheroidsSelf-healing hydrogel

Identifiers

PMID39756271
PMCPMC11827339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.