Evidence map›Paper›PMID 39756035›Full record

ArticleCell reports2025

Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs.

Kitra Cates, Luorongxin Yuan, Yan Yang, Andrew S Yoo

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kitra CatesDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Molecular Genetics and Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Luorongxin YuanDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Molecular Genetics and Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yan YangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew S YooDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yooa@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Modeling Neuronal Aging and Alzheimer's Disease in Human Neurons Directly Converted from FibroblastsRF1AG056296 · NIA · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2017 to 2017
$1.9M
Mechanistic insights into neurodegeneration in Huntington's disease using patient-derived neurons through direct conversion of fibroblastsR01NS107488 · NINDS · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2018 to 2022
$1.7M
Investigating non-coding RNA 7SK in Huntington's Disease neurodegeneration using direct neuronal conversionF31NS124128 · NINDS · WASHINGTON UNIVERSITY · PI CATES, KITRA L · 2022 to 2022
$33k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIA NIH HHS RF1 AG056296NIGMS NIH HHS T32 GM007067NINDS NIH HHS F31 NS124128NINDS NIH HHS R01 NS107488
6 · The paper itself

Abstract

Neurogenic microRNAs 9/9

Indexed as

Cellular ReprogrammingGene Regulatory NetworksMicroRNAsNeuronsAstrocytesFibroblastsHumansTumor Suppressor Protein p53MicroRNAsMIRN124 microRNA, humanMIRN92 microRNA, humanTumor Suppressor Protein p53cell fateCP: Molecular biologyCP: Stem cell researchdirect conversionfate erasuremicroRNAneuronal reprogrammingtranscriptomics

Identifiers

PMID39756035
PMCPMC11834941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.