Evidence map›Paper›PMID 39756015›Full record

SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

Disparities in Survival of Head and Neck Cancer in the Hispanic Population: Systematic-Review and Meta-analysis.

Alejandro R Marrero-Gonzalez, Douglas P Nanu, Shaun A Nguyen, Emily A Brennan, William Greer Albergotti, Bhisham S Chera, Jennifer L Harper, John M Kaczmar, Alexandra E Kejner, Jason G Newman and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alejandro R Marrero-GonzalezDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0001-7961-6112
Douglas P NanuDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0009-0007-6431-2432
Shaun A NguyenDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0003-0664-4571
Emily A BrennanMUSC Libraries, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0001-8463-1499
William Greer AlbergottiDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0003-1747-6593
Bhisham S CheraDepartment of Radiation Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0009-0003-2816-3557
Jennifer L HarperDepartment of Radiation Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.
John M KaczmarDivision of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0001-6785-7218
Alexandra E KejnerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0002-1999-2818
Jason G NewmanDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0002-4700-360X
Judith M SkonerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Evan M GraboyesDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID http://orcid.org/0000-0003-3766-468X

Funding

A Type I Hybrid Effectiveness-Implementation Trial to Evaluate a Navigation-Based Multilevel Intervention to Decrease Delays Starting Adjuvant Therapy Among Patients with Head and Neck CancerR01CA282165 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Evan Michael Graboyes · 2023 to 2026
$2.8M
Improving the Timeliness and Equity of Adjuvant Therapy Following Surgery for Head and Neck CancerK08CA237858 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRABOYES, EVAN MICHAEL · 2019 to 2023
$1.3M
NCI NIH HHS K08 CA237858NCI NIH HHS R01 CA282165
6 · The paper itself

Abstract

objectiveThe Hispanic health paradox (HHP), the observation that Hispanic people in the United States often experience better health outcomes than non-Hispanic people despite having worse prognostic factors, has not been evaluated for patients with head and neck squamous cell carcinoma (HNSCC), a malignancy with marked racial disparities in outcomes. The objective of this study is to evaluate the HHP within the context of HNSCC. DATA SOURCES: CINAHL, PubMed, and Scopus. REVIEW

methodsStudies that compared survival between Hispanic and non-Hispanic patients with HNSCC in the United States were included. Meta-analysis of adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) was conducted to compare overall survival (OS) and cancer-specific survival (CSS) between Hispanic white (HW) and non-Hispanic white (NHW) patients with HNSCC.

resultsOf 2106 unique abstracts reviewed, 25 studies were included in the systematic review and 22 in the meta-analysis. Among the 657,185 patients in the meta-analysis, 6.9% (95% CI: 5.8%-8.3%) were of Hispanic ethnicity. HW patients had improved OS relative to NHW patients (aHR = 0.90, 95% CI: 0.86-0.94) among the 17 studies reporting OS and improved CSS relative to NHW patients (aHR = 0.87, 95% CI: 0.80-0.94) among the 4 studies reporting this outcome.

conclusionHW people with HNSCC exhibit improved survival relative to NHW people with HNSCC, supporting the HHP in the context of HNSCC. Research is needed to understand the underlying mechanisms, which could provide insights into improving outcomes for all patients with HNSCC.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsHealth Status DisparitiesHispanic or LatinoHumansSquamous Cell Carcinoma of Head and NeckSurvival RateUnited Stateshead and neck squamous cell carcinomahealth disparitiesHispanic health paradox

Identifiers

PMID39756015
PMCPMC11949715

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.