ArticleDiscover oncology2025
The incidence of and risk factors for axillary web syndrome with limited shoulder movement after surgery for breast cancer, and the effect of early physical therapy intervention.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Predictive modeling of axillary web syndrome in Chinese postoperative breast cancer patients using interpretable machine learning.Frontiers in oncology · 2026Article
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5 authors.
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Abstract
backgroundThe aims of this cohort study were to identify (1) the incidence and risk factors for axillary web syndrome (AWS) with shoulder movement limitation within 4 weeks after axillary lymph node dissection (ALND) for Asian women with breast cancer (BC), and (2) whether early intervention with physical therapy (PT) could improve AWS, and how many PT sessions would be needed.
methodsA cohort study of patients with BC receiving ALND was performed at Changhua Christian Hospital, Taiwan, between January 2019 and December 2020. Those patients who were diagnosed with AWS with shoulder movement limitation were referred to receive PT twice weekly at the Department of Physical Medicine and Rehabilitation.
resultsA total 173 BC patients receiving ALND were enrolled. The incidence of AWS with shoulder movement limitation was 18%, and the time to diagnosis was 26.3 days. In a subsequent multivariate analysis, younger age (OR = 0.95; 95% CI = 0.91-0.99; p = 0.019), higher number of removed lymph nodes (OR = 1.09; 95% CI = 1.03-1.16; p = 0.007) and receiving neoadjuvant chemotherapy (NAC) (OR = 2.96; 95% CI = 1.25-6.98; p = 0.013) were associated with an increased risk of developing AWS with shoulder movement limitation. The corresponding area under the curve was 0.762. Initial shoulder flexion and abduction were 132.1° and 123.4°, respectively. After 14.8 PT sessions, shoulder flexion and abduction improved to 172.3° and 171.8°, respectively. Improvement in shoulder range of motion was 40.2° and 48.4° in flexion and abduction, respectively, which was significant (p < 0.001).
conclusionsIn conclusion, we demonstrated a prediction model for AWS with shoulder movement limitation using 3 risk factors: younger age, a higher number of removed lymph nodes, and receiving NAC. Approximately 18% of BC survivors will have AWS with shoulder function limitation during the first month after ALND. An early intervention protocol with a PT program could effectively restore shoulder function.
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