Evidence map›Paper›PMID 39755817›Full record

ArticleClinical rheumatology2025

Clinical characteristics of IgG4-related retroperitoneal fibrosis in a cohort of 117 patients with idiopathic retroperitoneal fibrosis: a retrospective study.

Jia-Qi Hu, Zheng-Yi Jin, Yi-Yi Yu, Du-Mu Min, Qing Cai, Jie Gao

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia-Qi HuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.ORCID http://orcid.org/0000-0001-5815-8802
Zheng-Yi JinDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.ORCID http://orcid.org/0009-0005-6477-3066
Yi-Yi YuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.ORCID http://orcid.org/0009-0004-9048-9117
Du-Mu MinDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.ORCID http://orcid.org/0009-0004-6739-3600
Qing CaiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. caiqing_2011@126.com.ORCID http://orcid.org/0000-0002-3928-8457
Jie GaoDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. chyygaojie@163.com.ORCID http://orcid.org/0000-0003-1075-3631

Funding

Scientific Research Project of Shanghai Municipal Health Commission 202340061the Special Cultivation Project of Basic Medical Research of the First Affiliated Hospital of Naval Medical University 2023PY40
6 · The paper itself

Abstract

objectiveRetroperitoneal fibrosis (RPF) is a rare condition marked by inflammation and fibrosis affecting the peritoneal and retroperitoneal soft tissues. In recent years, the identification of IgG4-related diseases has brought to light a significant association with fibrous disorders, including RPF, which were once considered independent. In this comprehensive cohort study, we performed a comparative analysis of the demographic, clinical, laboratory, histopathological, and therapeutic characteristics between patients with IgG4-related RPF and those with idiopathic retroperitoneal fibrosis (iRPF).

methodsWe performed a retrospective analysis of 117 patients diagnosed with RPF at the First Affiliated Hospital of Naval Medical University between July 2007 and July 2023.

resultsDemographic, clinical, laboratory, histopathological, and therapeutic characteristics of 70 iRPF patients and 47 IgG4-related patients were systematically compared. The IgG4-related group exhibited an older age of onset, with a predominant occurrence among adult males. Significantly elevated levels of eosinophilia and IgE were observed in the IgG4-related group. Most patients across both groups displayed elevated CRP and ESR levels. Furthermore, at the time of diagnosis, the IgG4-related group had higher serum creatinine and lower levels of complement. The most prevalent clinical manifestation in both groups was flank pain. The proportion of lymphoplasmic infiltration and storiform fibrosis in IgG4-related RPF group was significantly higher. The IgG4-related RPF group had significantly higher IgG4-positive plasma cell count, IgG4/total IgG ratio, and eosinophils count than that in iRPF group.

conclusionWe conducted a comparative analysis of demographic, clinical, laboratory, histopathological, and therapeutic differences between the iRPF patients and the IgG4-related patients. Clarifying the distinctive characteristics of these two groups will contribute to a better understanding of the condition and facilitate the development of specific treatment strategies tailored to each group. Key Points • Identification of distinct clinical features and outcomes between IgG4-related and iRPF patients in a large retrospective study.

Indexed as

Immunoglobulin GImmunoglobulin G4-Related DiseaseRetroperitoneal FibrosisAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesImmunoglobulin GClinical characteristicsIgG4-related diseaseRetroperitoneal fibrosis

Identifiers

PMID39755817

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