Evidence map›Paper›PMID 39755806›Full record

ArticleEye (London, England)2025

Ciliary muscle traction during accommodation is able to induce optic nerve head deformation.

Tingting Liu, Kehao Wang, Ya Xing Wang, Xiaoyu Liu, Jingyun Han, Michael J A Girard, Barbara K Pierscionek, Xiaofei Wang, Yubo Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tingting Liu *Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.ORCID http://orcid.org/0009-0005-1894-0740
Kehao Wang *Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Ya Xing WangBeijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0003-2749-7793
Xiaoyu LiuKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Jingyun HanKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Michael J A GirardSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Barbara K PierscionekFaculty of Health, Education, Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, UK.
Xiaofei WangKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China. xiaofei.wang@buaa.edu.cn.ORCID http://orcid.org/0000-0002-3175-0344
Yubo FanKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China. yubofan@buaa.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 12272030，12472304National Natural Science Foundation of China (National Science Foundation of China) 12372301
6 · The paper itself

Abstract

objectivesTo use finite element (FE) modeling and in vivo optical coherence tomography (OCT) imaging to explore the effect of ciliary muscle traction on optic nerve head (ONH) deformation during accommodation.

methodsWe developed a FE model to mimic the ciliary muscle traction during accommodation, and varied the stiffness of the sclera, choroid, Bruch's membrane (BM), prelaminar neural tissue and lamina cribrosa (LC) to assess their effects on accommodation-induced ONH strains. To validate the FE model, OCT images of the right eyes' ONHs from 20 subjects (25 ± 1.5 years, range: 24-28 years) were taken for an accommodative stimulus of 6-diopters (6D) and a relaxed state of 0D. Based on OCT images, the accommodation-induced ONH effective strains, choroidal thickness and BM opening (BMO) changes were measured.

resultsOur FE model predicted that the ciliary muscle pulling force could be transmitted to the ONH through the choroid and BM. The LC strain caused by the ciliary muscle pulling (0.0177) is comparable to that induced by an IOP elevation of 45 mmHg (0.0173). The accommodation-induced LC strain increased with stiffer choroid and BM. Three-dimensional strain tracking showed that the LC strains under 6D and 0D accommodation were 0.057 ± 0.033 and 0.023 ± 0.014 (p < 0.05). The reduction in choroidal thickness and the enlargement in BMO were observed during accommodation.

conclusionsOur study showed that during accommodation, ciliary muscle traction could induce large ONH deformations and that stiffer choroid and BM increased the pulling force transmitted to the ONH, thereby leading to higher LC strains.

Indexed as

Accommodation, OcularCiliary BodyMuscle, SmoothOptic DiskAdultBruch MembraneChoroidFemaleFinite Element AnalysisHumansIntraocular PressureMaleScleraTomography, Optical CoherenceYoung Adult

Identifiers

PMID39755806
PMCPMC11978995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.