Evidence map›Paper›PMID 39755797›Full record

ArticleScientific reports2025

Mendelian randomization analysis reveals causal relationship between depression, antidepressants and benign paroxysmal vertigo.

Yayun Liao, Kejian Zhou, Zhiyan Guo, Lu Qin, Shan Deng, Hong Yang, Baohui Weng, Liya Pan

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yayun Liao *Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Kejian Zhou *Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Zhiyan GuoDepartment of Rehabilitation, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Lu QinDepartment of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Shan DengDepartment of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Hong YangDepartment of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Baohui WengDepartment of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Liya PanDepartment of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China. Panlya@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benign paroxysmal vertigo (BPV) is a common cause of dizziness, and some patients are comorbid with psychiatric disorders such as depression, requiring intervention with antidepressants. However, the causal association between BPV, depression and antidepressants has not been clearly established. We used two-sample bidirectional Mendelian randomization (MR) to analyze the causal association between BPV, depression, and antidepressants. From a Finnish database, 43,280 patients with depression and 329,192 controls, and 106,785 patients with antidepressants and 88,536 controls were selected. Independent single nucleotide polymorphisms (SNPs) for depression and antidepressants were used as instrumental variables (IVs) with genomic significance (p < 5 × 10

Indexed as

Antidepressive AgentsBenign Paroxysmal Positional VertigoDepressionGenome-Wide Association StudyMendelian Randomization AnalysisPolymorphism, Single NucleotideCase-Control StudiesFemaleFinlandGenetic Predisposition to DiseaseHumansMaleAntidepressive AgentsAntidepressantsBenign paroxysmal vertigoDepressionGenome‐wide association studyMendelian randomization

Identifiers

PMID39755797
PMCPMC11700151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.