Evidence map›Paper›PMID 39755782›Full record

ArticleScientific reports2025

Atrophic meibomian gland dysfunction induced by eyelid margin cryotherapy with liquid nitrogen.

Shu Wang, Yulin Li, Jingfan Gao, Jia Lin, Xin Jin, Hong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shu WangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yulin LiEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jingfan GaoEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jia LinEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin JinEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hong ZhangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China. zhanghong@hrbmu.edu.cn.

Funding

Heilongjiang Provincial Department of Education Heilongjiang Provincial Higher Education Fundamental Research Project 2021-KYYWF-0226Heilongjiang Provincial key research and development plan guidance project GZ20220125National Natural Science Foundation of China No. U20A20363, 81970776, 82301173The Natural Science Foundation of Heilongjiang Province, China No. LH2020H039The Science Fund for Excellent Young Scholars of First Affiliated Hospital of Harbin Medical University No.2024YQ04
6 · The paper itself

Abstract

To develop an atrophic Meibomian Gland Dysfunction (MGD) animal model via liquid nitrogen cryotherapy, the eyelid edges of C57 mice exposure to liquid nitrogen for 30 s. Morphology of MG and ocular surface were assessed using stereomicroscopy and a slit lamp microscope at multiple time points post-injury. Acinar loss and atrophy were observed from day 7, with increased inflammation and apoptosis, and decreased proliferation in acinar cells. Corneal epithelial defects appeared after day 14. Liquid nitrogen induced selective damage to meibomian acinar cells, simulating MGD pathology effectively, with peak effects at day 21, providing a relevant model for atrophic MGD research.

Indexed as

AtrophyCryotherapyMeibomian Gland DysfunctionMeibomian GlandsNitrogenAcinar CellsAnimalsApoptosisDisease Models, AnimalEyelidsMaleMiceMice, Inbred C57BLNitrogenAcinar atrophyLiquid nitrogenMeibomian gland dysfunctionModel

Identifiers

PMID39755782
PMCPMC11700185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.