Evidence map›Paper›PMID 39755734›Full record

ArticleScientific reports2025

Unveiling nature's antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats.

Ali Imran Abid, Hira Muzammel, Mohsin Javed, Muhammad Muntazir Iqbal, Sajid Mahmood, Ammar Zidan, Fadi Jaber, K K Mujeeb Rahman, Ali Bahadur, Shahid Iqbal and 5 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ali Imran AbidDepartment of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Hira MuzammelDepartment of Pharmacology, Faculty of Pharmacy, Lahore College for Women University, Lahore, Pakistan.
Mohsin JavedDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan.
Muhammad Muntazir IqbalDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, 54770, Pakistan. muntaziriqbal121@gmail.com.
Sajid MahmoodNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China. sajidmahmood1987@yahoo.com.
Ammar ZidanBiomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babylon, 51001, Iraq.
Fadi JaberDepartment of Biomedical Engineering, Ajman University, Ajman, United Arab Emirates. f.jaber@ajman.ac.ae.
K K Mujeeb RahmanDepartment of Biomedical Engineering, Ajman University, Ajman, United Arab Emirates.
Ali BahadurNanomaterials Research Center, Department of Chemistry, College of Science, Mathematics, and Technology, Wenzhou-Kean University, Wenzhou, 325060, Zhejiang Province, China. abahadur@wku.edu.cn.
Shahid IqbalNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China. shahidiqbal@hzu.edu.cn.
Muhammad SaadCentre for Organic and Nanohybrid Electronics, Silesian University of Technology, Konarskiego 22B, 44-100, Gliwice, Poland. saad.miana786@gmail.com.
Ayed A DeraDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Yousif A AsiriTaif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Abd-ElAziem FaroukDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Salman AloufiDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.

Funding

Taif University TU-DSPP-2024-65
6 · The paper itself

Abstract

To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e., 151 mg/kg and 301 mg/kg to assess the anti-diabetic potential in normoglycemic, alloxan-induced and glucose-loaded diabetic rats. The effect of the seeds extract on total cholesterol and triglycerides was also assessed. Histological examination of the pancreas and the GC-MS analysis of blood and urine samples of rats were also carried out. At 151 mg/kg and 301 mg/kg doses, the aqueous methanolic extracts of Berberis orthobotrys seeds showed promising results for their anti-diabetic potential comparable to Glibenclamide. Studies on the phytochemistry of AMEBO also exposed the existence of alkaloids, steroids, glycosides, flavonoids and resins. Serum lipid measurements showed a substantial reduction in triglycerides and total cholesterol on days 7 and 15. The pancreas's islets were protected by the extract, as shown by a histological analysis. The primary metabolite Berberine, which was qualitatively detected by GC-MS in blood and urine samples of rats, may be the alkaloid in command of insulin release or recovery of beta cells after alloxan destruction. More study is necessary to comprehend the underlying signaling process.

Indexed as

AlloxanBerberisDiabetes Mellitus, ExperimentalHypoglycemic AgentsPlant ExtractsSeedsAnimalsBlood GlucoseCholesterolGas Chromatography-Mass SpectrometryMaleRatsRats, WistarAlloxanBlood GlucoseCholesterolHypoglycemic AgentsPlant ExtractsBerberis orthobotrysDiabetes mellitusGC-MSMetabolic irregularities

Identifiers

PMID39755734
PMCPMC11700095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.