Evidence map›Paper›PMID 39755716›Full record

ArticleCardio-oncology (London, England)2025

Cardiorespiratory fitness, cardiac morphology and function, and cardiovascular risk factors in long-term breast cancer survivors compared with non-cancer controls.

Mali Sæter, Sara Hassing Johansen, Kristin Valborg Reinertsen, Lene Thorsen, Kristina Hermann Haugaa, Tormod Skogstad Nilsen, Sebastian Imre Sarvari

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04307407 (The Cause Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04307407 nacompletednot on this map

The Cause Trial: A Randomized Trial of Aerobic Exercise on CVD Risk Factors in Breast Cancer Survivors

TypeinterventionalSponsorNorwegian School of Sport SciencesRan2020 to 2023Enrolled210ConditionsBreast CancerArmsAerobic Exercise
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mali SæterInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Sara Hassing JohansenDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.
Kristin Valborg ReinertsenDepartment of Oncology, Oslo University Hospital, Oslo, 0379, Norway.
Lene ThorsenDepartment of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
Kristina Hermann HaugaaInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Tormod Skogstad NilsenDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.
Sebastian Imre SarvariProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Oslo, Norway. sebims1@hotmail.com.

Funding

The Norwegian Cancer Society 202076
6 · The paper itself

Abstract

backgroundAlthough anthracycline-related cardiotoxicity is widely studied, only a limited number of echocardiographic studies have assessed cardiac function in breast cancer survivors (BCSs) beyond ten years from anthracycline treatment, and the knowledge of long-term cardiorespiratory fitness (CRF) in this population is scarce. This study aimed to compare CRF assessed as peak oxygen uptake (V̇O

methodsThe CAUSE (Cardiovascular Survivors Exercise) trial included 140 BCSs recruited through the Cancer Registry of Norway, who were diagnosed with breast cancer stage II to III between 2008 and 2012 and had received treatment with epirubicin, and 69 similarly aged activity level-matched controls. All the participants underwent blood sampling, blood pressure measurements, echocardiography and cardiopulmonary exercise testing from October 2020 to August 2022.

resultsBCSs were aged 59 ± 6 years and had received a cumulative dose of 357 (243 to 366) mg/m

conclusionWe found that CRF, cardiac function, and CV risk profile in BCSs examined a decade after treatment with anthracyclines were similar to that in women with no history of cancer.

trial registrationclinicaltrials.gov (NCT04307407) https://clinicaltrials.gov/ct2/show/NCT04307407 .

Indexed as

Breast cancerCancer survivorshipCardiorespiratory fitnessCardiotoxicityEchocardiography

Identifiers

PMID39755716
PMCPMC11699684

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.