ArticleNature communications2025
On-site biosignal amplification using a single high-spin conjugated polymer.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Tri-Acceptor Skeleton Balancing Ambipolar Mixed Ionic-Electronic Transport in Organic Conductors.Angewandte Chemie (International ed. in English) · 2026Article
- Damage-Free Passivation of Ambipolar OECTs with Fluoropolymer Film for Enhanced Performance and Stability Toward Reliable Biosignal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-gain and broadband in vivo amplifiers enabled by matched materials.Nature communications · 2026Article
- Face-on crystallization in ambipolar organic mixed conductors enables homogeneous light-modulated artificial neurons.National science review · 2026Article
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- High-Performance Ambipolar Organic Electrochemical Transistors Based on Diketopyrrolopyrrole-Dialkoxybithiazole Conjugated Polymers for Single-component Inverters.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic Modulation of OECT-Based Inverters for In Situ Electrophysiological Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration. Ambipolar organic electrochemical transistors (OECTs) are promising for this purpose due to their high transconductance, low operating voltage, biocompatibility, and suitability for miniaturized amplifier design. However, limitations in material performance and stability have hindered their application in biosignal amplification. Here, we propose using high-spin, hydrophilic conjugated polymers and a computational screening approach to address this challenge. We designed a high-spin polymer, namely P(TII-2FT), which exhibits satisfactory, stable, and balanced ambipolar OECT performance. The figure-of-merits achieved by the P(TII-2FT) devices surpass those of the current leading materials by 5 to 20 times, resulting in remarkable voltage gains while maintaining a compact form factor. Based on this amplifier, we have successfully achieved on-site capture and amplification of various electrophysiological signals with greatly enhanced signal quality.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.