Evidence map›Paper›PMID 39755677›Full record

ArticleNPJ Parkinson's disease2025

Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson's disease.

Luisa Di Menna, Marika Alborghetti, Maria Ilenia De Bartolo, Marina Borro, Giovanna Gentile, Manuela Zinni, Matteo Bologna, Carolina Cutrona, Giovanna D'Errico, Tiziana Imbriglio and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Luisa Di Menna *Department of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Marika Alborghetti *Departments of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-9327-6660
Maria Ilenia De Bartolo *Department of Clinical Neurophysiology, IRCCS Neuromed, Pozzilli, Italy.
Marina BorroNeuroscience, Mental Health, and Sensory Organs Clinical Neurophysiology, Sapienza University of Rome, Rome, Italy.
Giovanna GentileNeuroscience, Mental Health, and Sensory Organs Clinical Neurophysiology, Sapienza University of Rome, Rome, Italy.
Manuela ZinniInserm UMR1141 NeuroDiderot, Université Paris Cité, Paris, France.
Matteo BolognaDepartments of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Carolina CutronaDepartments of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Giovanna D'ErricoDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Tiziana ImbriglioDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Domenico BucciDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Sara MerloDepartment of Drug and Health Sciences, University of Catania, Catania, Italy.
Roxana Paula GinereteDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Rosamaria OrlandoDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Federica CarrilloInstitute of Genetics and Biophysics, Adriano Buzzati-Traverso, National Research Council, Naples, Italy.
Giorgio FortunatoInstitute of Genetics and Biophysics, Adriano Buzzati-Traverso, National Research Council, Naples, Italy.
Milena CannellaDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Maria Angela SortinoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Julien PansiotInserm UMR1141 NeuroDiderot, Université Paris Cité, Paris, France.
Olivier BaudInserm UMR1141 NeuroDiderot, Université Paris Cité, Paris, France.
Ferdinando NicolettiDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Valeria BrunoDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.
Maurizio SimmacoNeuroscience, Mental Health, and Sensory Organs Clinical Neurophysiology, Sapienza University of Rome, Rome, Italy.
Francesco Ernesto PontieriNeuroscience, Mental Health, and Sensory Organs Clinical Neurophysiology, Sapienza University of Rome, Rome, Italy.
Edoardo BianchiniNeuroscience, Mental Health, and Sensory Organs Clinical Neurophysiology, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-7955-3369
Domiziana RinaldiNeuroscience, Mental Health, and Sensory Organs Clinical Neurophysiology, Sapienza University of Rome, Rome, Italy.
Amalia de CurtisDepartment of Epidemiology and Prevention, IRCCS Neuromed, 86077, Pozzilli, Italy.
Giovanni De GaetanoDepartment of Epidemiology and Prevention, IRCCS Neuromed, 86077, Pozzilli, Italy.
Licia IacovielloDepartment of Epidemiology and Prevention, IRCCS Neuromed, 86077, Pozzilli, Italy.
Teresa EspositoDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.ORCID http://orcid.org/0000-0002-7879-8441
Alfredo BerardelliDepartments of Human Neurosciences, Sapienza University of Rome, Rome, Italy. alfredo.berardelli@uniroma1.it.
Giuseppe BattagliaDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli, Italy.

Funding

Ministero della Salute (Ministry of Health, Italy) RF-2018-123-68289Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) E64117000190001
6 · The paper itself

Abstract

Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved in synaptic regulation and neuroinflammation. mGlu3

Identifiers

PMID39755677
PMCPMC11700162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.