ArticleBMC oral health2025
A novel stable biomimetic adhesive coating for functionalization of orthodontic brackets against bacterial colonization and white spot lesions.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application-A Scoping Review.Materials (Basel, Switzerland) · 2026Review
- Evaluating antibacterial efficiency of orthodontic brackets coated with copper oxide, titanium dioxide and silver nanoparticles.Bioinformation · 2026Article
- Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges.International journal of nanomedicine · 2026Review
- A scientometric study on research trends and characteristics of randomized controlled trials in orthodontics.Journal of dental sciences · 2026Article
- Evaluation of enamel remineralization potential and anticariogenic efficacy of polydopamine coated biogenic amorphous calcium phosphate.Clinical oral investigations · 2025Article
- Evaluation of Cement Remaining After Debonding and Polishing in Lingual Multibracket Appliance Using Planning Imaging 3D Software.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the efficacy of polydopamine (PDA) functionalization on orthodontic brackets in inhibiting biofilm formation and promoting surface bioactivity to buffer the acidity of caries-causing bacteria around orthodontic brackets and prevent demineralization. The stability of the coating in artificial saliva (AS) and distilled water was evaluated, along with its effect on pH changes in simulated body fluid (SBF) and distilled water.
methodsMaxillary incisor orthodontic brackets underwent PDA functionalization using a dopamine hydrochloride solution following a specific protocol. Biofilm formation on both control (Br-0) and coated (Br-PDA) brackets was assessed immediately after coating and after two months of aging (Aged Br-PDA) in artificial saliva. The adherent biofilm bacteria on brackets were quantified with colony count assessment and optical density. Surface morphology, Bioactivity, and coating stability were analyzed using Scanning Electron Microscopy (SEM). Coated and uncoated samples were immersed in SBF and deionized water, and pH changes were monitored over 7 days using a pH meter.
resultsPDA-functionalized brackets, both freshly coated (1.08 OD) and aged for two months (1.6 OD), showed significantly reduced biofilm formation compared to non-functionalized control brackets (2.07 OD), with p-value < 0.05. This reduction was confirmed through optical density measurements and colony-forming unit (CFU) counts (1.63E + 06, 4.53E + 07, and 7.56E + 07 respectively, p-value < 0.05). SEM analysis revealed alterations in surface morphology and composition, suggesting enhanced biointeraction in the coated brackets. Stability assessments in artificial saliva and deionized water demonstrated the durability of the coating. pH measurements indicated minimal changes in SBF and water, with PDA-functionalized brackets showing slight alterations.
conclusionsOur research findings suggest that PDA-functionalized brackets possess promising antimicrobial properties and stability, offering potential applications in orthodontic treatment to mitigate biofilm formation and prevent white spot lesions around orthodontic brackets. Further investigation is required to optimize the coating formulation and explore its long-term efficacy in clinical settings.
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