Evidence map›Paper›PMID 39755573›Full record

ArticleBMJ open2025

Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial.

Zhengfang Hu, Kangda Zhang, Youxuan Wu, Xinyan Wang, Zihui Zhang, Xuan Hou, Minyu Jian, Yunzhen Wang, Haiyang Liu, Anxin Wang and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06224426 (Oxygenation Targets for Endovascular Therapy in Acute Ischemic Stroke Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06224426 narecruitingnot on this map

Oxygenation Targets for Endovascular Therapy in Acute Ischemic Stroke Patients (Oxy-TARGET)

TypeinterventionalSponsorBeijing Tiantan HospitalRan2024 to 2026Enrolled200ConditionsIschemic StrokeArmsNormobaric high-concentration oxygen, Normobaric low-concentration oxygen
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhengfang Hu *Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.ORCID http://orcid.org/0000-0001-6956-7070
Kangda Zhang *Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Youxuan WuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Xinyan WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Zihui ZhangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Xuan HouDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Minyu JianDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Yunzhen WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Haiyang LiuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Anxin WangDepartment of Statistics, China National Clinical Research Center for Neurological Diseases, Beijing, PR China.
Ruquan Han *Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China ruquan.han@gmail.com liangfa1001@163.com.ORCID http://orcid.org/0000-0003-4335-8670
Fa Liang *Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China ruquan.han@gmail.com liangfa1001@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreclinical studies have shown that oxygen therapy can improve ischaemic brain tissue oxygen tension, reduce reperfusion injury after revascularisation, promote neuroregeneration and inhibit inflammatory responses potentially exerting a beneficial effect after endovascular treatment (EVT) in patients with acute ischaemic stroke (AIS). However, the optimal fraction of inspired oxygen (FiO METHODS AND ANALYSIS: The Oxy-TARGET trial is an ongoing prospective, open-label, parallel-design RCT being conducted at Beijing Tiantan Hospital, Capital Medical University. It aims to enrol 200 anterior circulation AIS patients undergoing EVT under general anaesthesia between February 2024 and December 2026. Eligible participants are randomly assigned at a 1:1 ratio to receive FiO ETHICS AND DISSEMINATION: Following a rigorous review process, Oxy-TARGET has received official approval from the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (KY2023-257-02). The standardised research protocol adopted in this trial is designed to enhance anaesthesiologists' understanding of respiratory management for AIS patients during EVT. The findings of this study are intended to be disseminated through publications in international peer-reviewed journals, presentations at national and international academic conferences and broad distribution via online platforms. TRIAL REGISTRATION NUMBER: NCT06224426.

Indexed as

Endovascular ProceduresIschemic StrokeOxygen Inhalation TherapyFemaleHumansMaleOxygenProspective StudiesRandomized Controlled Trials as TopicOxygenAnaesthesia in neurologyStrokeStroke medicineSTROKE MEDICINE

Identifiers

PMID39755573
PMCPMC11751949

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.