ArticleThe Journal of nutrition2025
Mice Born to Mothers Fed a Diet High in Omega-6 Fatty Acids and Low in Omega-3 Fatty Acids During Pregnancy Exhibit Various Behavioral Changes Including Impaired Social Behaviors and Enhanced Recognition Memory.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundModern dietary trends have led to an increase in foods that are relatively high in n-6 PUFAs and low in n-3 PUFAs. We previously reported that the offspring of mother mice that consumed a diet high in n-6 linoleic acid (LA) and low in n-3 α-linolenic acid (ALA), hereinafter called the LA
objectivesWe currently lack a comprehensive overview of the behavioral abnormalities in these offspring, which was investigated in this study.
methodsC57BL/6J virgin female mice at 11 wk of age were fed either a control diet or the LA
resultsBoth male and female offspring exposed in utero to the LA
conclusionsThe maternal balance between dietary n-6 and n-3 PUFAs during pregnancy can have significant effects on the offspring's behaviors, lasting well into adulthood.
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