Evidence map›Paper›PMID 39755094›Full record

ArticlePlacenta2025

Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome.

Alison Paquette, Mariana Parenti, Samantha Lapehn, Chaini Konwar, Leena Kadam, Evan J Firsick, Emily S Barrett, Julie MacIsaac, James MacDonald, Theo Bammler and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alison PaquetteSeattle Children's Research Institute, Seattle WA, USA; University of Washington, Seattle WA, USA. Electronic address: Alison.Paquette@seattlechildrens.org.
Mariana ParentiSeattle Children's Research Institute, Seattle WA, USA.
Samantha LapehnSeattle Children's Research Institute, Seattle WA, USA.
Chaini KonwarUniversity of British Columbia, Vancouver BC, Canada.
Leena KadamOregon Health & Sciences University, Oregon WA, USA.
Evan J FirsickSeattle Children's Research Institute, Seattle WA, USA.
Emily S BarrettRutgers University, Piscataway NJ, USA; University of Rochester, Rochester NY, USA.
Julie MacIsaacUniversity of British Columbia, Vancouver BC, Canada.
James MacDonaldUniversity of Washington, Seattle WA, USA.
Theo BammlerUniversity of Washington, Seattle WA, USA.
Kecia CarrollMount Sinai Medical Center, New York, NY, USA.
Daniel EnquobahrieUniversity of Washington, Seattle WA, USA.
Michael KoborUniversity of British Columbia, Vancouver BC, Canada.
Kaja Z LeWinnUniversity of California San Francisco, San Francisco CA, USA.
Ruby NguyenUniversity of Minnesota, Minneapolis, MN, USA.
Roger SmithHunter Medical Research Institute, University of Newcastle, Newcastle, USA.
Adam SpirzoUniversity of Washington, Seattle WA, USA.
Qi ZhaoUniversity of Tennessee Health Sciences Center, Memphis TN, USA.
Leslie MyattOregon Health & Sciences University, Oregon WA, USA.
Nicole R BushUniversity of California San Francisco, San Francisco CA, USA.
Louis MugliaThe Burroughs Wellcome Fund, Research Triangle Park NC, USA.
Sheela SathyanarayanaSeattle Children's Research Institute, Seattle WA, USA; University of Washington, Seattle WA, USA.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung FunctionR01HL132338 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE, WRIGHT, ROSALIND J · 2017 to 2021
$3.8M
The Role of Corticotrophin Releasing Hormone on Placental Transcriptional Networks and Birth TimingR00HD096112 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI PAQUETTE, ALISON GENEVIEVE · 2020 to 2022
$721k
The role of Corticotrophin Releasing Hormone on placental transcriptional networks and birth timingK99HD096112 · NICHD · INSTITUTE FOR SYSTEMS BIOLOGY · PI PAQUETTE, ALISON GENEVIEVE · 2018 to 2019
$258k
NCATS NIH HHS UL1 TR002319NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL132338NICHD NIH HHS K99 HD096112NICHD NIH HHS R00 HD096112NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES007033NIH HHS UG3 OD023271NIH HHS UH3 OD023271
6 · The paper itself

Abstract

introductionThe placenta produces corticotrophin releasing hormone (CRH), which rises exponentially in maternal plasma across pregnancy. CRH plays a functional role in fetal development, labor initiation, and the regulation of gestational length. We aimed to understand how maternal plasma CRH during pregnancy reflects placental physiology during parturition by characterizing placental transcriptomic signatures of maternal plasma CRH and comparing to transcriptomic signatures of gestational age at birth.

methodsMaternal plasma CRH concentrations were measured via radioimmunoassay at two timepoints and the placental transcriptome was quantified via RNA sequencing in 516 pregnant participants enrolled in the CANDLE cohort. Robust linear models were fitted to estimate associations between CRH and placental gene expression at birth. We conducted a functional validation in primary trophoblast cells before and after syncytialization.

resultsPlasma CRH concentrations in the mid-pregnancy visit were associated with placental expression of 8 differentially expressed genes (DEGs), and concentrations in late pregnancy were associated with 283 DEGs. These genes were involved in several metabolic pathways. Seven genes were significantly associated with both plasma CRH and gestational length. Four genes were concordantly decreased and 7 genes were concordantly increased in primary trophoblasts treated with CRH. DISCUSSION: Overall, this study reveals potential novel transcriptional mechanisms by which CRH may regulate metabolic pathways important for placental function and identifies genes associated with both CRH and gestational length.

Indexed as

Corticotropin-Releasing HormonePlacentaTranscriptomeAdultFemaleHumansPregnancyCorticotropin-Releasing HormoneCorticotrophin releasing hormoneParturitionPlacentaTranscriptomics

Identifiers

PMID39755094
PMCPMC11980646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.