Evidence map›Paper›PMID 39754894›Full record

ArticleCancer genetics2025

Analysis of nuclear receptor expression in head and neck cancer.

Lindsey Mortensen, Cynthia K Koenigsberg, Tyler G Kimbrough, Jesse Ping, Gema Souto Adeva, Beverly R Wuertz, Patrick Gaffney, Frank G Ondrey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lindsey MortensenDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA. Electronic address: morte303@umn.edu.
Cynthia K KoenigsbergDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Tyler G KimbroughDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Jesse PingDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Gema Souto AdevaDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Beverly R WuertzDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Patrick GaffneyOklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Frank G OndreyDepartment of Otolaryngology, University of Minnesota, MMC396, 420 Delaware St SE, Minneapolis, MN 55455, USA.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
Pioglitazone-Metformin Combination Treatment for High Risk Oral PreneoplasiaR01CA254270 · NCI · UNIVERSITY OF MINNESOTA · PI ONDREY, FRANK G. · 2022 to 2025
$1.7M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA254270
6 · The paper itself

Abstract

objectiveStudies of squamous cell carcinoma of the head and neck (HNSCC) have demonstrated the importance of nuclear receptors and their associated coregulators in the development and treatment of HNSCC. We sought to characterize members of the nuclear receptor super family through interrogation of RNA-Seq and microarray data. MATERIALS AND

methodsTCGA RNA-Seq data within the cBioportal platform comparing HNSCC samples (n = 515 patients with RNA-Seq data) to normal tissue (n = 82 patients) was interrogated for significant differences in nuclear receptor expression. Affymetrix microarray analysis of HNSCC tumors relative to normal oral mucosa (41 tumor, 13 normal) was analyzed.

resultsOf the 48 NR genes and 19 NR cofactors examined, 99 % of tumor samples in the TCGA had some form of NR gene 'alteration' compared to normal tissue. These alterations predominantly encompass expression changes. NR genes (PPARG) and (RORC), and the NR cofactor, (NCOA1), were differentially expressed and downregulated in tumors compared to normal tissue.

conclusionWe have discovered significant decreases in PPARG expression with co-occurring changes in genes involved with lipid metabolism and cell cycle progression in HNSCC. We are targeting PPARγ with thiazolidinediones in a series of clinical trials to restore normal signaling via differentiation to hopefully reverse carcinogenesis. We also observed several receptors with differential expression associated with clinical factors that may become the focus of interest in future targeting efforts. These data provide evidence for nuclear receptors playing a role in the dysregulation of gene expression in HNSCC and illustrate the utility of current bioinformatic tools for interrogating complex, high throughput data sets.

Indexed as

Head and Neck NeoplasmsReceptors, Cytoplasmic and NuclearFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMalePPAR gammaSquamous Cell Carcinoma of Head and NeckPPAR gammaReceptors, Cytoplasmic and NuclearChemopreventionHead and neck cancerNuclear receptorRetinoic acidTcga

Identifiers

PMID39754894
PMCPMC11800142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.