Evidence map›Paper›PMID 39754757›Full record

ReviewCurrent medicinal chemistry2025

Recent Advances in Synthetic Strategies of Glycans and their Pharmaceutical Applications.

He Wang, Marco Terreni, Matthieu Sollogoub, Yongmin Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

He WangInstitut Parisien de Chimie Moléculaire, CNRS, Sorbonne Université,, UMR 8232, 4 Place Jussieu, Paris, 75005, France.
Marco TerreniDrug Sciences Department, University of Pavia, Viale Taramelli 12, Pavia, 27100, Italy.
Matthieu SollogoubInstitut Parisien de Chimie Moléculaire, CNRS, Sorbonne Université,, UMR 8232, 4 Place Jussieu, Paris, 75005, France.
Yongmin ZhangInstitut Parisien de Chimie Moléculaire, CNRS, Sorbonne Université,, UMR 8232, 4 Place Jussieu, Paris, 75005, France.

Funding

China Scholarship Council (CSC) 202208070019
6 · The paper itself

Abstract

The understanding of glycans, the third life chain, is widely desired. Naturally, the glycoconjugates are found in heterogeneous forms due to the enzyme competition in the same process. As a result, the synthesis of homogeneous glycans has become one of the trending research topics. In this review, orthogonal protection strategies were summarized to overcome the difficulties, such as the numerous hydroxyl groups of oligosaccharides and stereoselectivities during glycosylations. A variety of synthetic glycomics, including glycoproteins, glycolipids, and newly discovered glycoRNAs, were also presented. Their applications were categorized by different diseases, which elucidated the great potential of glycans as drug candidates in the next generation.

Indexed as

PolysaccharidesGlycoproteinsGlycosylationHumansGlycoproteinsPolysaccharidesGlycansglycolipidsglycoproteinsglycornasoligosaccharidesorganic synthesisorthogonal protection strategiespharmaceutical applications.

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.