Evidence map›Paper›PMID 39754704›Full record

ReviewProbiotics and antimicrobial proteins2025

Probiotics Exert Gut Immunomodulatory Effects by Regulating the Expression of Host miRNAs.

Wenjing Li, Yongwei Zeng, Jiayu Zhong, Youyu Hu, Xia Xiong, Yingshun Zhou, Li Fu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  9. Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjing LiDepartment of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Yongwei ZengDepartment of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Jiayu ZhongDepartment of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Youyu HuDepartment of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Xia XiongDepartment of Dermatology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Yingshun ZhouDepartment of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, China. yingshunzhou@swmu.edu.cn.
Li FuDepartment of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China. fuli001@swmu.edu.cn.

Funding

Project of Luzhou Science and Technology Bureau and Southwest Medical University 2023LZXNYDHZ001Sichuan Province Science and Technology project 2022YFS0631the Southwest Medical University Foundation 2021ZKZD002
6 · The paper itself

Abstract

Probiotics exert a diverse range of immunomodulatory effects on the human gut immune system. These mechanisms encompass strengthening the intestinal mucosal barrier, inhibiting pathogen adhesion and colonization, stimulating immune modulation, and fostering the production of beneficial substances. As a result, probiotics hold significant potential in the prevention and treatment of various conditions, including inflammatory bowel disease and colorectal cancer. A pivotal mechanism by which probiotics achieve these effects is through modulating the expression of host miRNAs. miRNAs, non-coding RNA molecules, are vital regulators of fundamental biological processes like cell growth, differentiation, and apoptosis. By interacting with mRNAs, miRNAs can either promote their degradation or repress their translation, thereby regulating gene expression post-transcriptionally and modulating the immune system. This review provides a comprehensive overview of how probiotics modulate gut immune responses by altering miRNA expression levels, both upregulating and downregulating specific miRNAs. It further delves into how this modulation impacts the host's resistance to pathogens and susceptibility to diseases, offering a theoretical foundation and practical insights for the clinical utilization of probiotics in disease prevention and therapy.

Indexed as

ImmunomodulationMicroRNAsProbioticsAnimalsGastrointestinal MicrobiomeGene Expression RegulationHumansIntestinal MucosaMicroRNAsCancerImmune systemInflammatory bowel disease (IBD)MiRNAsProbioticsRegulating

Identifiers

PMID39754704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.