Evidence map›Paper›PMID 39754513›Full record

ArticleJournal of perinatal medicine2025

Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes.

Emiko Takeoka, April A Carlson, Neel Madan, Afshin Azimirad, Taysir Mahmoud, Rie Kitano, Shizuko Akiyama, Hyuk Jin Yun, Richard Tucker, Kiho Im and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emiko TakeokaTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
April A CarlsonTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
Neel MadanDepartment of Radiology, Mass General Brigham, Boston, MA, USA.
Afshin AzimiradTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
Taysir MahmoudTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
Rie KitanoTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.ORCID https://orcid.org/0000-0002-9679-3791
Shizuko AkiyamaTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
Hyuk Jin YunFetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Richard TuckerDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
Kiho ImFetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Perrie O'Tierney-GinnTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.
Tomo TaruiTufts Medical Center, Mother Infant Research Institute, Boston, MA, USA.ORCID https://orcid.org/0000-0003-3860-7062

Funding

Placental lipid metabolism impacts fetal adiposity and is programmed by the maternal metabolic milieu in early pregnancyR01HD091054 · NICHD · TUFTS MEDICAL CENTER · PI O'TIERNEY-GINN, PERRIE F · 2017 to 2022
$2.5M
Prenatal diagnosis of brain malformations: Improving assessment of prognosisK23HD079605 · NICHD · TUFTS MEDICAL CENTER · PI TARUI, TOMO · 2015 to 2019
$767k
NICHD NIH HHS K23 HD079605NICHD NIH HHS R01 HD091054
6 · The paper itself

Abstract

objectivesMaternal obesity increases a child's risk of neurodevelopmental impairment. However, little is known about the impact of maternal obesity on fetal brain development.

methodsWe prospectively recruited 20 healthy pregnant women across the range of pre-pregnancy or first-trimester body mass index (BMI) and performed fetal brain magnetic resonance imaging (MRI) of their healthy singleton fetuses. We examined correlations between early pregnancy maternal BMI and regional brain volume of living fetuses using volumetric MRI analysis.

resultsOf 20 fetuses, there were 8 males and 12 females (median gestational age at MRI acquisition was 24.3 weeks, range: 19.7-33.3 weeks, median maternal age was 33.3 years, range: 22.0-37.4 years). There were no significant differences in clinical demographics between overweight (OW, 25≤BMI<30)/obese (OB, BMI≥30 kg/m

conclusionsThis pilot study supports the concept that maternal obesity impacts fetal brain volume, detectable via MRI in living fetuses using quantitative analysis.

Indexed as

Body Mass IndexCerebellumCerebral CortexFetal DevelopmentPregnancy in ObesityAdultFemaleGestational AgeHumansMagnetic Resonance ImagingMaleOrgan SizePregnancyProspective StudiesYoung Adultfetal brain development and growthfetal brain MRImaternal obesityMRI analysis

Identifiers

PMID39754513
PMCPMC13379884

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.