Evidence map›Paper›PMID 39754303›Full record

ArticleCNS neuroscience & therapeutics2025

Peripheral Single-Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies.

Conglong Qiu, Danhua Zhang, Majie Wang, Xi Mei, Wei Chen, Haihang Yu, Weiwei Yin, Guoping Peng, Shaohua Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Conglong QiuDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0009-0002-8193-646X
Danhua ZhangDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Majie WangDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Xi MeiDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.ORCID 0000-0002-5091-8747
Wei ChenKey Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Haihang YuDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Weiwei YinKey Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Guoping PengDepartment of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID 0000-0002-6706-8670
Shaohua HuDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0003-0570-670X

Funding

Chinese Medical Education Association 2022KTZ004Innovation team for precision diagnosis and treatment of major brain diseases 2020R01001Leading Talent of Scientific and Technological Innovation Ten Thousand Talents Program of Zhejiang Province 2021R52016National Key Research and Development Program of China 2022YFC3602604National Key Research and Development Program of China 2023YFC2506200NINGBO Medical Health Leading Academic Discipline Project 2022 F28Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL 2023001BZhejiang Provincial Key Research and Development Program 2021C03107
6 · The paper itself

Abstract

objectiveAlzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common neurodegenerative diseases with distinct but overlapping pathogenic mechanisms. The clinical similarities between these diseases often result in high misdiagnosis rates, leading to serious consequences. Peripheral blood mononuclear cells (PBMCs) are easy to collect and can accurately reflect the immune characteristics of both DLB and AD.

methodsWe utilized time-of-flight mass cytometry (CyTOF) with single-cell resolution to quantitatively analyze peripheral PBMCs, identifying 1228 immune characteristics. Based on the top-selected immune features, we constructed immunological elastic net (iEN) models.

resultsThese models demonstrated high diagnostic efficacy in distinguishing diseased samples from healthy donors as well as distinguishing AD and DLB cases. The selected features reveal that the primary peripheral immune characteristic of AD is a decrease in total T cells, while DLB is characterized by low expression of I-kappa-B-alpha (IKBα) in the classical monocyte subset.

conclusionsThese findings suggest that peripheral immune characteristics could serve as potential biomarkers, facilitating the diagnosis of neurodegenerative diseases.

Indexed as

Alzheimer DiseaseLeukocytes, MononuclearLewy Body DiseaseAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedSingle-Cell AnalysisT-LymphocytesBiomarkersAlzheimer's diseasedementia with Lewy bodiessingle‐cell analysis

Identifiers

PMID39754303
PMCPMC11702477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.