Evidence map›Paper›PMID 39754290›Full record

ArticleJournal of chemical theory and computation2025

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl

Linda X Phan, Aaron P Owji, Tingting Yang, Jason Crain, Mark S P Sansom, Stephen J Tucker

Abstract read
In one paragraph

Article in Journal of chemical theory and computation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Linda X PhanDepartment of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU, U.K.
Aaron P OwjiDepartment of Ophthalmology, Columbia University, New York, New York 10032, United States.
Tingting YangDepartment of Ophthalmology, Columbia University, New York, New York 10032, United States.
Jason CrainDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K.ORCID 0000-0001-8672-9158
Mark S P SansomDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K.
Stephen J TuckerDepartment of Physics, Clarendon Laboratory, University of Oxford, Oxford OX1 3PU, U.K.ORCID 0000-0001-8996-2000

Funding

Mechanistic Characterization of Calcium-Activated Chloride Channels in Retinal Pigment EpitheliumR01GM127652 · NIGMS · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2018 to 2022
$1.7M
Interacting Partners of Bestrophin ChannelsR35GM149252 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Tingting Yang · 2023 to 2026
$1.6M
NIGMS NIH HHS R01 GM127652NIGMS NIH HHS R35 GM149252
6 · The paper itself

Abstract

Mechanisms of anion permeation within ion channels and nanopores remain poorly understood. Recent cryo-electron microscopy structures of the human bestrophin 1 Cl

Indexed as

BestrophinsCryoelectron MicroscopyElectronsHumansMolecular Dynamics SimulationBEST1 protein, humanBestrophins

Identifiers

PMID39754290
PMCPMC11780730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.