Evidence map›Paper›PMID 39754206›Full record

ArticleGenome biology2025

SMORE: spatial motifs reveal patterns in cellular architecture of complex tissues.

Zainalabedin Samadi, Kai Hao, Amjad Askary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Zainalabedin SamadiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 90095, CA, USA.
Kai HaoDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 90095, CA, USA.
Amjad AskaryDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 90095, CA, USA. amjada@ucla.edu.ORCID http://orcid.org/0000-0002-2913-8498

Funding

Synthetic recording and in situ readout of cell lineage and molecular history in mammalian retinaR00EY031782 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASKARY, AMJAD · 2022 to 2024
$747k
NEI NIH HHS 5R00EY031782-05NEI NIH HHS R00 EY031782
6 · The paper itself

Abstract

Deciphering the link between tissue architecture and function requires methods to identify and interpret patterns in spatial arrangement of cells. We present SMORE, an approach to detect patterns in sequential arrangements of cells and examine their associated gene expression specializations. Applied to retina, brain, and embryonic tissue maps, SMORE identifies novel spatial motifs, including one that offers a new mechanism of action for type 1b bipolar cells. Structural signatures detected by SMORE also form a basis for classifying tissues. Together, our method provides a new framework for uncovering spatial complexity in tissue organization and offers novel insights into tissue function.

Indexed as

BrainRetinaAnimalsHumansMiceOrgan SpecificityRetinal Bipolar CellsNeighborhood graphsNetwork motifsSpatial transcriptomicsUniform path sampling

Identifiers

PMID39754206
PMCPMC11697875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.