ArticleBMC geriatrics2025
Frailty as a mediator between sleep quality and cognitive impairment among the rural older adults: a cross-sectional study.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Joint trajectories of sleep deviation risk and frailty and their associations with cognitive decline in middle-aged and older adults: a population-based cohort study.BMC public health · 2026Article
- Interpretable machine learning-based predictive model for fall risk in older adults receiving maintenance hemodialysis.Frontiers in medicine · 2026Article
- Sleep quality in older adults with cognitive frailty: current status and influencing factors.BMC geriatrics · 2025Article
- The interaction of physical activity and sleep quality with depression and anxiety in older adults.Frontiers in public health · 2025Article
- Association of sleep duration and sleep quality with cognitive frailty in Chinese older adults.Frontiers in public health · 2025Article
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11 authors.
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Abstract
backgroundCognitive impairment is a common health problem among older adults. Previous studies have proven the association between sleep quality and cognitive impairment, but the specific underlying mechanisms need to be further explored. This study aimed to examine the relationship between sleep quality and cognitive impairment and the mediating effect of frailty in this relationship among the rural older adults.
methodsData from a cross-sectional study conducted in rural areas of Shandong Province from September to December in 2023. A total of 695 rural older adults were included. The Pittsburgh Sleep Quality Index (PSQI) was used to measure sleep quality. Frailty was defined using the FRAIL scale. We assessed cognitive impairment using the Dementia Screening Interview (AD8). Logistic regression analyse was used to assess the relationship between sleep quality and cognitive impairment. And the Karlson-Holm-Breen (KHB) method was performed to test the mediating role of frailty in this relationship.
resultsAfter adjusting for all covariates, sleep quality was significantly associated with cognitive impairment (OR = 1.047, 95% CI: 1.005-1.090). Frailty mediated the relationship between sleep quality and cognitive impairment, with a mediation effect value of 0.010 (95% CI: 0.001-0.020), accounting for 17.86% of the total effect.
conclusionsWe found there was an association between sleep quality and cognitive impairment, and frailty mediated the above relationship. Comprehensive intervention measures should be taken to reduce the incidence of frailty in the older adults and to improve their sleep quality, thereby preventing and delaying the occurrence and development of cognitive impairment.
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